Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins

SARS-CoV-2 infection or vaccination produces neutralizing antibody responses that contribute to better clinical outcomes. The receptor-binding domain (RBD) and the N-terminal domain (NTD) of the spike trimer (S) constitute the two major neutralizing targets for antibodies. Here, we use NTD-specific...

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Detalles Bibliográficos
Autores principales: Wang, Zijun, Muecksch, Frauke, Cho, Alice, Gaebler, Christian, Hoffmann, Hans-Heinrich, Ramos, Victor, Zong, Shuai, Cipolla, Melissa, Johnson, Briana, Schmidt, Fabian, DaSilva, Justin, Bednarski, Eva, Ben Tanfous, Tarek, Raspe, Raphael, Yao, Kaihui, Lee, Yu E., Chen, Teresia, Turroja, Martina, Milard, Katrina G., Dizon, Juan, Kaczynska, Anna, Gazumyan, Anna, Oliveira, Thiago Y., Rice, Charles M., Caskey, Marina, Bieniasz, Paul D., Hatziioannou, Theodora, Barnes, Christopher O., Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986478/
https://www.ncbi.nlm.nih.gov/pubmed/35447092
http://dx.doi.org/10.1016/j.immuni.2022.04.003

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