ZAP70, too little, too much can lead to autoimmunity

Establishing both central and peripheral tolerance requires the appropriate TCR signaling strength to discriminate self‐ from agonist‐peptide bound to self MHC molecules. ZAP70, a cytoplasmic tyrosine kinase, directly interacts with the TCR complex and plays a central and requisite role in TCR signa...

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Detalles Bibliográficos
Autores principales: Ashouri, Judith F., Lo, Wan‐Lin, Nguyen, Trang T. T., Shen, Lin, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Invited Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986586/
https://www.ncbi.nlm.nih.gov/pubmed/34923645
http://dx.doi.org/10.1111/imr.13058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986586/
https://www.ncbi.nlm.nih.gov/pubmed/34923645
http://dx.doi.org/10.1111/imr.13058

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