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ZAP70, too little, too much can lead to autoimmunity
Establishing both central and peripheral tolerance requires the appropriate TCR signaling strength to discriminate self‐ from agonist‐peptide bound to self MHC molecules. ZAP70, a cytoplasmic tyrosine kinase, directly interacts with the TCR complex and plays a central and requisite role in TCR signa...
Autores principales: | Ashouri, Judith F., Lo, Wan‐Lin, Nguyen, Trang T. T., Shen, Lin, Weiss, Arthur |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986586/ https://www.ncbi.nlm.nih.gov/pubmed/34923645 http://dx.doi.org/10.1111/imr.13058 |
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