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Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis

BACKGROUND: The number of days of preoperative hospital stay (PHS) is a modifiable variable that has shown contradictory surgical site infection (SSI) risk factor results in neurosurgery. We sought to pinpoint the day of PHS length related with a marked increase of risk of SSI. METHODS: From a terti...

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Autores principales: Cediel, Emilio Garzón, Boerwinkle, Varina Louise, Ramon, Juan Fernando, Arias, Diana, De la Hoz-Valle, Jose Antonio, Mercado, Jose Dario, Cohen, Darwin, Niño, Maria Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986656/
https://www.ncbi.nlm.nih.gov/pubmed/35399909
http://dx.doi.org/10.25259/SNI_1237_2021
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author Cediel, Emilio Garzón
Boerwinkle, Varina Louise
Ramon, Juan Fernando
Arias, Diana
De la Hoz-Valle, Jose Antonio
Mercado, Jose Dario
Cohen, Darwin
Niño, Maria Claudia
author_facet Cediel, Emilio Garzón
Boerwinkle, Varina Louise
Ramon, Juan Fernando
Arias, Diana
De la Hoz-Valle, Jose Antonio
Mercado, Jose Dario
Cohen, Darwin
Niño, Maria Claudia
author_sort Cediel, Emilio Garzón
collection PubMed
description BACKGROUND: The number of days of preoperative hospital stay (PHS) is a modifiable variable that has shown contradictory surgical site infection (SSI) risk factor results in neurosurgery. We sought to pinpoint the day of PHS length related with a marked increase of risk of SSI. METHODS: From a tertiary teaching hospital, January 2015–December 2017, prospectively collected nonpercutaneous neurosurgery procedures with standard antibiotic prophylaxis and 1-year follow-up were evaluated. SSI risk factors were assessed through multiple logistic regression models with different thresholds of PHS. RESULTS: A total of 1012 procedures were included in the study. Incidence of SSI was 4.4%. The median PHS was higher in those with SSI than in those without (1 day, interquartile range [IQR]: 7 vs. 0 days, IQR: 1, respectively, P = 0.002). By the amount of six days of PHS, this exposure risk past the threshold of significance for impact on wound infection (OR 2.8; CI 1.23–6.39, P = 0.014). Operative time past 4 h (OR 2.11; CI 1.12-3.98; P = 0.021), and in some models, previous surgery at same admission were also identified by multivariate analysis as increasing postoperative SSI risk. CONCLUSION: The gradual increase of the SSI OR associated with longer PHS days was the highest risk factor of SSI in our cohort of patients. Studies directed to reduce this complication should consider the PHS.
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spelling pubmed-89866562022-04-07 Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis Cediel, Emilio Garzón Boerwinkle, Varina Louise Ramon, Juan Fernando Arias, Diana De la Hoz-Valle, Jose Antonio Mercado, Jose Dario Cohen, Darwin Niño, Maria Claudia Surg Neurol Int Original Article BACKGROUND: The number of days of preoperative hospital stay (PHS) is a modifiable variable that has shown contradictory surgical site infection (SSI) risk factor results in neurosurgery. We sought to pinpoint the day of PHS length related with a marked increase of risk of SSI. METHODS: From a tertiary teaching hospital, January 2015–December 2017, prospectively collected nonpercutaneous neurosurgery procedures with standard antibiotic prophylaxis and 1-year follow-up were evaluated. SSI risk factors were assessed through multiple logistic regression models with different thresholds of PHS. RESULTS: A total of 1012 procedures were included in the study. Incidence of SSI was 4.4%. The median PHS was higher in those with SSI than in those without (1 day, interquartile range [IQR]: 7 vs. 0 days, IQR: 1, respectively, P = 0.002). By the amount of six days of PHS, this exposure risk past the threshold of significance for impact on wound infection (OR 2.8; CI 1.23–6.39, P = 0.014). Operative time past 4 h (OR 2.11; CI 1.12-3.98; P = 0.021), and in some models, previous surgery at same admission were also identified by multivariate analysis as increasing postoperative SSI risk. CONCLUSION: The gradual increase of the SSI OR associated with longer PHS days was the highest risk factor of SSI in our cohort of patients. Studies directed to reduce this complication should consider the PHS. Scientific Scholar 2022-03-04 /pmc/articles/PMC8986656/ /pubmed/35399909 http://dx.doi.org/10.25259/SNI_1237_2021 Text en Copyright: © 2022 Surgical Neurology International https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Cediel, Emilio Garzón
Boerwinkle, Varina Louise
Ramon, Juan Fernando
Arias, Diana
De la Hoz-Valle, Jose Antonio
Mercado, Jose Dario
Cohen, Darwin
Niño, Maria Claudia
Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis
title Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis
title_full Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis
title_fullStr Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis
title_full_unstemmed Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis
title_short Length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: A cohort data-driven analysis
title_sort length of preoperative hospital stay is the dominating risk factor for surgical site infection in neurosurgery: a cohort data-driven analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986656/
https://www.ncbi.nlm.nih.gov/pubmed/35399909
http://dx.doi.org/10.25259/SNI_1237_2021
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