The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease

This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patien...

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Autores principales: Zapała, Barbara, Stefura, Tomasz, Piwowar, Monika, Czekalska, Sylwia, Zawada, Magdalena, Hadasik, Maria, Solnica, Bogdan, Rudzińska-Bar, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986734/
https://www.ncbi.nlm.nih.gov/pubmed/35044623
http://dx.doi.org/10.1007/s12031-022-01966-3
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author Zapała, Barbara
Stefura, Tomasz
Piwowar, Monika
Czekalska, Sylwia
Zawada, Magdalena
Hadasik, Maria
Solnica, Bogdan
Rudzińska-Bar, Monika
author_facet Zapała, Barbara
Stefura, Tomasz
Piwowar, Monika
Czekalska, Sylwia
Zawada, Magdalena
Hadasik, Maria
Solnica, Bogdan
Rudzińska-Bar, Monika
author_sort Zapała, Barbara
collection PubMed
description This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson’s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (p = 0.001) and resulted in parts II and III of the UPDRS scale (p = 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (p = 0.001) and resulted in parts II and III of the UPDRS scale (p = 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD.
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spelling pubmed-89867342022-04-22 The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease Zapała, Barbara Stefura, Tomasz Piwowar, Monika Czekalska, Sylwia Zawada, Magdalena Hadasik, Maria Solnica, Bogdan Rudzińska-Bar, Monika J Mol Neurosci Article This study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson’s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (p = 0.001) and resulted in parts II and III of the UPDRS scale (p = 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (p = 0.001) and resulted in parts II and III of the UPDRS scale (p = 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD. Springer US 2022-01-19 2022 /pmc/articles/PMC8986734/ /pubmed/35044623 http://dx.doi.org/10.1007/s12031-022-01966-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zapała, Barbara
Stefura, Tomasz
Piwowar, Monika
Czekalska, Sylwia
Zawada, Magdalena
Hadasik, Maria
Solnica, Bogdan
Rudzińska-Bar, Monika
The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
title The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
title_full The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
title_fullStr The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
title_full_unstemmed The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
title_short The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
title_sort role of single nucleotide polymorphisms of monoamine oxidase b, dopamine d2 receptor, and dopa decarboxylase receptors among patients treated for parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986734/
https://www.ncbi.nlm.nih.gov/pubmed/35044623
http://dx.doi.org/10.1007/s12031-022-01966-3
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