Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer

PURPOSE: Downregulation of miRNA-22 in triple-negative breast cancer (TNBC) is associated with upregulation of eukaryotic elongation 2 factor kinase (eEF2K) protein, which regulates tumor growth, chemoresistance, and tumor immunosurveillance. Moreover, exogenous administration of miRNA-22, loaded in...

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Detalles Bibliográficos
Autores principales: Dogra, Prashant, Ramírez, Javier Ruiz, Butner, Joseph D., Peláez, Maria J., Chung, Caroline, Hooda-Nehra, Anupama, Pasqualini, Renata, Arap, Wadih, Cristini, Vittorio, Calin, George A., Ozpolat, Bulent, Wang, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986735/
https://www.ncbi.nlm.nih.gov/pubmed/35294699
http://dx.doi.org/10.1007/s11095-022-03176-3

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