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Architecture of the human NALCN channelosome

NALCN regulates the resting membrane potential by mediating the Na(+) leak current in neurons, and it functions as a channelosome in complex with FAM155A, UNC79, and UNC80. Dysfunction of the NALCN channelosome causes a broad range of neurological and developmental diseases called NALCN channelopath...

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Detalles Bibliográficos
Autores principales: Zhou, Lunni, Liu, Haobin, Zhao, Qingqing, Wu, Jianping, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986805/
https://www.ncbi.nlm.nih.gov/pubmed/35387979
http://dx.doi.org/10.1038/s41421-022-00392-4