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Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level
Regular hepatocellular carcinoma (HCC) surveillance by ultrasonography in combination with the α-fetoprotein (AFP) examination is unsatisfactory in diagnostic sensitivity for early-stage HCC especially in cirrhotic patients. We conducted a prospective study in a tertiary medical center in Taiwan and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986837/ https://www.ncbi.nlm.nih.gov/pubmed/35388082 http://dx.doi.org/10.1038/s41598-022-09713-9 |
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author | Wu, Jin-Lin Su, Tung-Hung Chen, Pei-Jer Chen, Yun-Ru |
author_facet | Wu, Jin-Lin Su, Tung-Hung Chen, Pei-Jer Chen, Yun-Ru |
author_sort | Wu, Jin-Lin |
collection | PubMed |
description | Regular hepatocellular carcinoma (HCC) surveillance by ultrasonography in combination with the α-fetoprotein (AFP) examination is unsatisfactory in diagnostic sensitivity for early-stage HCC especially in cirrhotic patients. We conducted a prospective study in a tertiary medical center in Taiwan and consecutively collected serum samples from patients with chronic hepatitis, liver cirrhosis (LC), or HCC for new biomarker discovery. Overall, 166 patients were enrolled, including 40 hepatitis, 30 LC, and 96 HCC. Four acute-phase serum amyloid A (A-SAA) derived biomarkers including total A-SAA, A-SAA monomer and oligomer, and protein misfolding cyclic amplification (PMCA) signal were measured and compared between patients with and without HCC. A-SAA biomarkers significantly increased in the HCC group when compared to the hepatitis and LC groups, and generally increased in more advanced tumor stages. Among A-SAA biomarkers, the area under the receiver operator characteristic curves (AUROCs) for PMCA signal in discrimination of all-stage and early-stage HCC were 0.86 and 0.9 in cirrhotic patients, which is comparable to AFP. For cirrhotic patients with low AFP (< 7 ng/mL), PMCA signal maintained good capacity in prediction of early-stage HCC (AUROC: 0.94). Serum A-SAA and its prion-like property showed a potential to complement AFP in detection of early-stage HCC. |
format | Online Article Text |
id | pubmed-8986837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89868372022-04-08 Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level Wu, Jin-Lin Su, Tung-Hung Chen, Pei-Jer Chen, Yun-Ru Sci Rep Article Regular hepatocellular carcinoma (HCC) surveillance by ultrasonography in combination with the α-fetoprotein (AFP) examination is unsatisfactory in diagnostic sensitivity for early-stage HCC especially in cirrhotic patients. We conducted a prospective study in a tertiary medical center in Taiwan and consecutively collected serum samples from patients with chronic hepatitis, liver cirrhosis (LC), or HCC for new biomarker discovery. Overall, 166 patients were enrolled, including 40 hepatitis, 30 LC, and 96 HCC. Four acute-phase serum amyloid A (A-SAA) derived biomarkers including total A-SAA, A-SAA monomer and oligomer, and protein misfolding cyclic amplification (PMCA) signal were measured and compared between patients with and without HCC. A-SAA biomarkers significantly increased in the HCC group when compared to the hepatitis and LC groups, and generally increased in more advanced tumor stages. Among A-SAA biomarkers, the area under the receiver operator characteristic curves (AUROCs) for PMCA signal in discrimination of all-stage and early-stage HCC were 0.86 and 0.9 in cirrhotic patients, which is comparable to AFP. For cirrhotic patients with low AFP (< 7 ng/mL), PMCA signal maintained good capacity in prediction of early-stage HCC (AUROC: 0.94). Serum A-SAA and its prion-like property showed a potential to complement AFP in detection of early-stage HCC. Nature Publishing Group UK 2022-04-06 /pmc/articles/PMC8986837/ /pubmed/35388082 http://dx.doi.org/10.1038/s41598-022-09713-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wu, Jin-Lin Su, Tung-Hung Chen, Pei-Jer Chen, Yun-Ru Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level |
title | Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level |
title_full | Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level |
title_fullStr | Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level |
title_full_unstemmed | Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level |
title_short | Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level |
title_sort | acute-phase serum amyloid a for early detection of hepatocellular carcinoma in cirrhotic patients with low afp level |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986837/ https://www.ncbi.nlm.nih.gov/pubmed/35388082 http://dx.doi.org/10.1038/s41598-022-09713-9 |
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