Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that cells exploit a sphingomyelin-based lysosomal repair pathway that operates independently of ESCRT to reverse potentiall...

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Detalles Bibliográficos
Autores principales: Niekamp, Patrick, Scharte, Felix, Sokoya, Tolulope, Vittadello, Laura, Kim, Yeongho, Deng, Yongqiang, Südhoff, Elisabeth, Hilderink, Angelika, Imlau, Mirco, Clarke, Christopher J., Hensel, Michael, Burd, Christopher G., Holthuis, Joost C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986845/
https://www.ncbi.nlm.nih.gov/pubmed/35388011
http://dx.doi.org/10.1038/s41467-022-29481-4

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