Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study

The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an accumulation of intracellular sorbitol, depletion of cytoplasmic NADPH and oxidative stress and causing a variety of different conditions includin...

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Detalles Bibliográficos
Autores principales: Imran, Aqeel, Shehzad, Muhammad Tariq, Shah, Syed Jawad Ali, al Adhami, Taha, Laws, Mark, Rahman, Khondaker Miraz, Alharthy, Rima D., Khan, Imtiaz Ali, Shafiq, Zahid, Iqbal, Jamshed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986850/
https://www.ncbi.nlm.nih.gov/pubmed/35388067
http://dx.doi.org/10.1038/s41598-022-09658-z

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