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Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model

PURPOSE: There is a great need to reduce the toxicity of chemotherapy used in the management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional pressurized delivery of oxaliplatin can minimize peripheral neuropathy in mice. METHODS: We used an orthotopic PDAC mouse model and del...

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Detalles Bibliográficos
Autores principales: Shankara Narayanan, Jayanth Surya Narayanan, Frizzi, Katie, Erdem, Suna, Ray, Partha, Jaroch, David, Cox, Bryan, Katz, Steven, Vicente, Diego, White, Rebekah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986945/
https://www.ncbi.nlm.nih.gov/pubmed/35384564
http://dx.doi.org/10.1007/s12672-022-00483-4