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SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran
Estimating the prevalence of SARS-CoV-2 antibody seropositivity among health care workers (HCWs) is crucial. In this study, the seroprevalence of anti-SARS-CoV-2 antibodies among HCWs of five hospitals of Tehran, Iran with high COVID-19 patient's referrals from April to June, 2020, was assessed...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987007/ https://www.ncbi.nlm.nih.gov/pubmed/35400056 http://dx.doi.org/10.3389/fpubh.2022.832003 |
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author | Darvishian, Maryam Sharafkhah, Maryam Mohammadi, Zahra Sadeghniiat-haghighi, Khosro Abdollahi, Alireza Jafary, Mohamadreza Talaschian, Mona Tabarsi, Payam Baghai, Parvaneh Mardani, Masoud Shayanrad, Amaneh Shafighian, Fatemeh Markarian, Melineh Roozafzai, Farzin Zamani, Mohammad Alvand, Saba Hariri, Sanam Sadeghi, Anahita Poustchi, Hossein Malekzadeh, Reza |
author_facet | Darvishian, Maryam Sharafkhah, Maryam Mohammadi, Zahra Sadeghniiat-haghighi, Khosro Abdollahi, Alireza Jafary, Mohamadreza Talaschian, Mona Tabarsi, Payam Baghai, Parvaneh Mardani, Masoud Shayanrad, Amaneh Shafighian, Fatemeh Markarian, Melineh Roozafzai, Farzin Zamani, Mohammad Alvand, Saba Hariri, Sanam Sadeghi, Anahita Poustchi, Hossein Malekzadeh, Reza |
author_sort | Darvishian, Maryam |
collection | PubMed |
description | Estimating the prevalence of SARS-CoV-2 antibody seropositivity among health care workers (HCWs) is crucial. In this study, the seroprevalence of anti-SARS-CoV-2 antibodies among HCWs of five hospitals of Tehran, Iran with high COVID-19 patient's referrals from April to June, 2020, was assessed. In this cross-sectional study, HCWs from three public and two private hospitals, selected randomly as a pilot, were included. Participants were asked questions on their demographic characteristics, medical history, hospital role, and usage of personal protective equipment (PPE). Iran FDA-approved SARS-CoV-2 ELISA kits were used to detect IgG and IgM antibodies in blood samples. The seroprevalence was estimated on the basis of ELISA test results and adjusted for test performance. Among the 2,065 participants, 1,825 (88.4%) and 240 (11.6%) HCWs were recruited from public and private hospitals, respectively. A total of 340 HCWs were tested positive for SARS-CoV-2-specific IgG or IgM antibodies, and 17.9% of seropositive individuals were asymptomatic. The overall test performance-adjusted seroprevalence estimate among HCWs was 22.6 (95% CI: 20.2–25.1), and PPE usage was significantly higher among HCWs of public vs. private hospitals (66.5 vs. 20.0%). This study found that seroprevalence of SARS-CoV-2 among HCWs was higher in private hospitals (37.0%; 95% CI: 28.6–46.2) than public hospitals (20.7%; 95% CI: 18.2–23.3), and also highest among assistant nurses and nurses, and lowest among janitor or superintendent categories. The PPE usage was especially suboptimal among HCWs in private hospitals. Continued effort in access to adequate PPE and regular screening of hospital staff for detecting asymptomatic personnel, especially during the upcoming wave of infection, are warranted. |
format | Online Article Text |
id | pubmed-8987007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89870072022-04-08 SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran Darvishian, Maryam Sharafkhah, Maryam Mohammadi, Zahra Sadeghniiat-haghighi, Khosro Abdollahi, Alireza Jafary, Mohamadreza Talaschian, Mona Tabarsi, Payam Baghai, Parvaneh Mardani, Masoud Shayanrad, Amaneh Shafighian, Fatemeh Markarian, Melineh Roozafzai, Farzin Zamani, Mohammad Alvand, Saba Hariri, Sanam Sadeghi, Anahita Poustchi, Hossein Malekzadeh, Reza Front Public Health Public Health Estimating the prevalence of SARS-CoV-2 antibody seropositivity among health care workers (HCWs) is crucial. In this study, the seroprevalence of anti-SARS-CoV-2 antibodies among HCWs of five hospitals of Tehran, Iran with high COVID-19 patient's referrals from April to June, 2020, was assessed. In this cross-sectional study, HCWs from three public and two private hospitals, selected randomly as a pilot, were included. Participants were asked questions on their demographic characteristics, medical history, hospital role, and usage of personal protective equipment (PPE). Iran FDA-approved SARS-CoV-2 ELISA kits were used to detect IgG and IgM antibodies in blood samples. The seroprevalence was estimated on the basis of ELISA test results and adjusted for test performance. Among the 2,065 participants, 1,825 (88.4%) and 240 (11.6%) HCWs were recruited from public and private hospitals, respectively. A total of 340 HCWs were tested positive for SARS-CoV-2-specific IgG or IgM antibodies, and 17.9% of seropositive individuals were asymptomatic. The overall test performance-adjusted seroprevalence estimate among HCWs was 22.6 (95% CI: 20.2–25.1), and PPE usage was significantly higher among HCWs of public vs. private hospitals (66.5 vs. 20.0%). This study found that seroprevalence of SARS-CoV-2 among HCWs was higher in private hospitals (37.0%; 95% CI: 28.6–46.2) than public hospitals (20.7%; 95% CI: 18.2–23.3), and also highest among assistant nurses and nurses, and lowest among janitor or superintendent categories. The PPE usage was especially suboptimal among HCWs in private hospitals. Continued effort in access to adequate PPE and regular screening of hospital staff for detecting asymptomatic personnel, especially during the upcoming wave of infection, are warranted. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC8987007/ /pubmed/35400056 http://dx.doi.org/10.3389/fpubh.2022.832003 Text en Copyright © 2022 Darvishian, Sharafkhah, Mohammadi, Sadeghniiat-haghighi, Abdollahi, Jafary, Talaschian, Tabarsi, Baghai, Mardani, Shayanrad, Shafighian, Markarian, Roozafzai, Zamani, Alvand, Hariri, Sadeghi, Poustchi and Malekzadeh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Darvishian, Maryam Sharafkhah, Maryam Mohammadi, Zahra Sadeghniiat-haghighi, Khosro Abdollahi, Alireza Jafary, Mohamadreza Talaschian, Mona Tabarsi, Payam Baghai, Parvaneh Mardani, Masoud Shayanrad, Amaneh Shafighian, Fatemeh Markarian, Melineh Roozafzai, Farzin Zamani, Mohammad Alvand, Saba Hariri, Sanam Sadeghi, Anahita Poustchi, Hossein Malekzadeh, Reza SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran |
title | SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran |
title_full | SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran |
title_fullStr | SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran |
title_full_unstemmed | SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran |
title_short | SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran |
title_sort | sars-cov-2 seroprevalence among health care workers in major private and public hospitals with covid-19 patient's referral in tehran, iran |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987007/ https://www.ncbi.nlm.nih.gov/pubmed/35400056 http://dx.doi.org/10.3389/fpubh.2022.832003 |
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