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The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

INTRODUCTION: We aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years. MATERIALS AND METHODS: We utilised cross-sectional data...

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Autores principales: Constable, Annie M., Vlachopoulos, Dimitris, Barker, Alan R., Moore, Sarah A., Soininen, Sonja, Haapala, Eero A., Väistö, Juuso, Jääskeläinen, Jarmo, Voutilainen, Raimo, Auriola, Seppo, Häkkinen, Merja R., Laitinen, Tomi, Lakka, Timo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987010/
https://www.ncbi.nlm.nih.gov/pubmed/35399927
http://dx.doi.org/10.3389/fendo.2022.850448
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author Constable, Annie M.
Vlachopoulos, Dimitris
Barker, Alan R.
Moore, Sarah A.
Soininen, Sonja
Haapala, Eero A.
Väistö, Juuso
Jääskeläinen, Jarmo
Voutilainen, Raimo
Auriola, Seppo
Häkkinen, Merja R.
Laitinen, Tomi
Lakka, Timo A.
author_facet Constable, Annie M.
Vlachopoulos, Dimitris
Barker, Alan R.
Moore, Sarah A.
Soininen, Sonja
Haapala, Eero A.
Väistö, Juuso
Jääskeläinen, Jarmo
Voutilainen, Raimo
Auriola, Seppo
Häkkinen, Merja R.
Laitinen, Tomi
Lakka, Timo A.
author_sort Constable, Annie M.
collection PubMed
description INTRODUCTION: We aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years. MATERIALS AND METHODS: We utilised cross-sectional data from the Physical Activity and Nutrition in Children study (n = 230 to 396; 112 to 203 girls). Fat mass and BMC were assessed with dual-energy X-ray absorptiometry. Endocrine factors were assessed from fasted blood samples. We applied the novel 4-way decomposition method to analyse associations between fat mass, endocrine factors, and BMC. RESULTS: Fat mass was positively associated with BMC in girls (ß = 0.007 to 0.015, 95% confidence interval (CI) 0.005 to 0.020) and boys (ß = 0.009 to 0.015, 95% CI 0.005 to 0.019). The relationship between fat mass and BMC was mediated by free leptin index in girls (ß = -0.025, 95% CI -0.039 to -0.010) and boys (ß = -0.014, 95% CI -0.027 to -0.001). The relationship between fat mass and BMC was partially explained by mediated interaction between fat mass and free leptin index in boys (ß = -0.009, 95% CI -0.013 to -0.004) and by interaction between fat mass and adiponectin in girls (ß = -0.003, 95% CI -0.006 to -0.000). CONCLUSION: At greater levels of adiponectin and free leptin index, the fat mass and BMC relationship becomes less positive in girls and boys respectively. The positive association between fat mass with BMC was largely not explained by the endocrine factors we assessed. CLINICAL TRIAL REGISTRATION: [https://clinicaltrials.gov/ct2/show/NCT01803776], identifier NCT01803776.
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spelling pubmed-89870102022-04-08 The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study Constable, Annie M. Vlachopoulos, Dimitris Barker, Alan R. Moore, Sarah A. Soininen, Sonja Haapala, Eero A. Väistö, Juuso Jääskeläinen, Jarmo Voutilainen, Raimo Auriola, Seppo Häkkinen, Merja R. Laitinen, Tomi Lakka, Timo A. Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: We aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years. MATERIALS AND METHODS: We utilised cross-sectional data from the Physical Activity and Nutrition in Children study (n = 230 to 396; 112 to 203 girls). Fat mass and BMC were assessed with dual-energy X-ray absorptiometry. Endocrine factors were assessed from fasted blood samples. We applied the novel 4-way decomposition method to analyse associations between fat mass, endocrine factors, and BMC. RESULTS: Fat mass was positively associated with BMC in girls (ß = 0.007 to 0.015, 95% confidence interval (CI) 0.005 to 0.020) and boys (ß = 0.009 to 0.015, 95% CI 0.005 to 0.019). The relationship between fat mass and BMC was mediated by free leptin index in girls (ß = -0.025, 95% CI -0.039 to -0.010) and boys (ß = -0.014, 95% CI -0.027 to -0.001). The relationship between fat mass and BMC was partially explained by mediated interaction between fat mass and free leptin index in boys (ß = -0.009, 95% CI -0.013 to -0.004) and by interaction between fat mass and adiponectin in girls (ß = -0.003, 95% CI -0.006 to -0.000). CONCLUSION: At greater levels of adiponectin and free leptin index, the fat mass and BMC relationship becomes less positive in girls and boys respectively. The positive association between fat mass with BMC was largely not explained by the endocrine factors we assessed. CLINICAL TRIAL REGISTRATION: [https://clinicaltrials.gov/ct2/show/NCT01803776], identifier NCT01803776. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC8987010/ /pubmed/35399927 http://dx.doi.org/10.3389/fendo.2022.850448 Text en Copyright © 2022 Constable, Vlachopoulos, Barker, Moore, Soininen, Haapala, Väistö, Jääskeläinen, Voutilainen, Auriola, Häkkinen, Laitinen and Lakka https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Constable, Annie M.
Vlachopoulos, Dimitris
Barker, Alan R.
Moore, Sarah A.
Soininen, Sonja
Haapala, Eero A.
Väistö, Juuso
Jääskeläinen, Jarmo
Voutilainen, Raimo
Auriola, Seppo
Häkkinen, Merja R.
Laitinen, Tomi
Lakka, Timo A.
The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
title The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
title_full The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
title_fullStr The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
title_full_unstemmed The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
title_short The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
title_sort mediating role of endocrine factors in the positive relationship between fat mass and bone mineral content in children aged 9–11 years: the physical activity and nutrition in children study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987010/
https://www.ncbi.nlm.nih.gov/pubmed/35399927
http://dx.doi.org/10.3389/fendo.2022.850448
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