Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within t...

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Autores principales: Kishimoto-Urata, Megumi, Urata, Shinji, Kagoya, Ryoji, Imamura, Fumiaki, Nagayama, Shin, Reyna, Rachel A., Maruyama, Junki, Yamasoba, Tatsuya, Kondo, Kenji, Hasegawa-Ishii, Sanae, Paessler, Slobodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987081/
https://www.ncbi.nlm.nih.gov/pubmed/35388072
http://dx.doi.org/10.1038/s41598-022-09731-7
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author Kishimoto-Urata, Megumi
Urata, Shinji
Kagoya, Ryoji
Imamura, Fumiaki
Nagayama, Shin
Reyna, Rachel A.
Maruyama, Junki
Yamasoba, Tatsuya
Kondo, Kenji
Hasegawa-Ishii, Sanae
Paessler, Slobodan
author_facet Kishimoto-Urata, Megumi
Urata, Shinji
Kagoya, Ryoji
Imamura, Fumiaki
Nagayama, Shin
Reyna, Rachel A.
Maruyama, Junki
Yamasoba, Tatsuya
Kondo, Kenji
Hasegawa-Ishii, Sanae
Paessler, Slobodan
author_sort Kishimoto-Urata, Megumi
collection PubMed
description The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.
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spelling pubmed-89870812022-04-08 Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit Kishimoto-Urata, Megumi Urata, Shinji Kagoya, Ryoji Imamura, Fumiaki Nagayama, Shin Reyna, Rachel A. Maruyama, Junki Yamasoba, Tatsuya Kondo, Kenji Hasegawa-Ishii, Sanae Paessler, Slobodan Sci Rep Article The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome. Nature Publishing Group UK 2022-04-06 /pmc/articles/PMC8987081/ /pubmed/35388072 http://dx.doi.org/10.1038/s41598-022-09731-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kishimoto-Urata, Megumi
Urata, Shinji
Kagoya, Ryoji
Imamura, Fumiaki
Nagayama, Shin
Reyna, Rachel A.
Maruyama, Junki
Yamasoba, Tatsuya
Kondo, Kenji
Hasegawa-Ishii, Sanae
Paessler, Slobodan
Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
title Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
title_full Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
title_fullStr Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
title_full_unstemmed Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
title_short Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
title_sort prolonged and extended impacts of sars-cov-2 on the olfactory neurocircuit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987081/
https://www.ncbi.nlm.nih.gov/pubmed/35388072
http://dx.doi.org/10.1038/s41598-022-09731-7
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