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Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?

This brief report documents the safety and efficacy of high-dose tigecycline as a salvage-therapy in in a case series of five patients with serious central nervous system (CNS) rocky mountain spotted fever (RMSF). These severily ill patients were unable to take any oral drug therapy, parenteral doxy...

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Autores principales: Mastroianni, Antonio, Greco, Sonia, Urso, Filippo, Mauro, Maria Vittoria, Vangeli, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases; Korean Society for Antimicrobial Therapy; The Korean Society for AIDS 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987170/
https://www.ncbi.nlm.nih.gov/pubmed/35384427
http://dx.doi.org/10.3947/ic.2021.0070
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author Mastroianni, Antonio
Greco, Sonia
Urso, Filippo
Mauro, Maria Vittoria
Vangeli, Valeria
author_facet Mastroianni, Antonio
Greco, Sonia
Urso, Filippo
Mauro, Maria Vittoria
Vangeli, Valeria
author_sort Mastroianni, Antonio
collection PubMed
description This brief report documents the safety and efficacy of high-dose tigecycline as a salvage-therapy in in a case series of five patients with serious central nervous system (CNS) rocky mountain spotted fever (RMSF). These severily ill patients were unable to take any oral drug therapy, parenteral doxycycline was unavailable and absorption of oral doxycycline was a concern in these critically ill patients. As far as we know, we report the successfull use of tigecycline for the treatment of rickettsial meningitis for the first time in Italy. We suggest more studies on tigecycline in severe CNS infections from Rickettsia species and multi-drug resistant bacteria, especially the use of tigecycline at higher than standard doses in these life-threathening infectious diseases.
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spelling pubmed-89871702022-04-13 Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System? Mastroianni, Antonio Greco, Sonia Urso, Filippo Mauro, Maria Vittoria Vangeli, Valeria Infect Chemother Brief Communication This brief report documents the safety and efficacy of high-dose tigecycline as a salvage-therapy in in a case series of five patients with serious central nervous system (CNS) rocky mountain spotted fever (RMSF). These severily ill patients were unable to take any oral drug therapy, parenteral doxycycline was unavailable and absorption of oral doxycycline was a concern in these critically ill patients. As far as we know, we report the successfull use of tigecycline for the treatment of rickettsial meningitis for the first time in Italy. We suggest more studies on tigecycline in severe CNS infections from Rickettsia species and multi-drug resistant bacteria, especially the use of tigecycline at higher than standard doses in these life-threathening infectious diseases. The Korean Society of Infectious Diseases; Korean Society for Antimicrobial Therapy; The Korean Society for AIDS 2022-03 2022-03-10 /pmc/articles/PMC8987170/ /pubmed/35384427 http://dx.doi.org/10.3947/ic.2021.0070 Text en Copyright © 2022 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, and The Korean Society for AIDS https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Mastroianni, Antonio
Greco, Sonia
Urso, Filippo
Mauro, Maria Vittoria
Vangeli, Valeria
Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?
title Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?
title_full Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?
title_fullStr Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?
title_full_unstemmed Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?
title_short Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System?
title_sort does tigecycline have a place in therapy for rickettsial infection of the central nervous system?
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987170/
https://www.ncbi.nlm.nih.gov/pubmed/35384427
http://dx.doi.org/10.3947/ic.2021.0070
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