Nephrotic Syndrome Associated with Buerger's Disease

We herein report a 43-year-old woman with Buerger's disease who presented with nephrotic syndrome, renal dysfunction, and mild hypertension. A kidney biopsy revealed focal segmental glomerulosclerosis (FSGS), but there were no findings associated with frequent secondary FSGS or a history of lon...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Nahomi, Fukuda, Akihiro, Furutera, Norihiro, Kimoto, Miyuki, Maruo, Misaki, Kudo, Akiko, Aoki, Kohei, Nakata, Takeshi, Uesugi, Noriko, Fukunaga, Naoya, Shibata, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987250/
https://www.ncbi.nlm.nih.gov/pubmed/34471027
http://dx.doi.org/10.2169/internalmedicine.7885-21
Descripción
Sumario:We herein report a 43-year-old woman with Buerger's disease who presented with nephrotic syndrome, renal dysfunction, and mild hypertension. A kidney biopsy revealed focal segmental glomerulosclerosis (FSGS), but there were no findings associated with frequent secondary FSGS or a history of long-term hypertension. A small focal renal infarction was seen on (99m)Tc-dimercaptosuccinic acid renal scintigraphy, suggesting that FSGS was due to renal microinfarction associated with Buerger's disease. After the commencement of angiotensin-converting enzyme inhibitor therapy, the hypertension immediately improved, along with significant attenuation of proteinuria. Renal ischemia by vasoconstriction of the glomerular efferent arterioles in association with Buerger's disease may result in glomerular hyperfiltration followed by FSGS.

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