Persistent Hypoglycemia Induced by Long-acting Insulin Degludec

A 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464...

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Detalles Bibliográficos
Autores principales: Katakura, Yukino, Tatsumi, Fuminori, Kusano, Takashi, Shimoda, Masashi, Kohara, Kenji, Kimura, Tomohiko, Obata, Atsushi, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987256/
https://www.ncbi.nlm.nih.gov/pubmed/34483209
http://dx.doi.org/10.2169/internalmedicine.7915-21
Descripción
Sumario:A 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464 g. It took over three weeks for exogenous insulin to be almost undetectable. While degludec binds to albumin and exerts glucose-lowering effects for a long time, the above-mentioned period of three weeks was consistent with the half-life of albumin. Hypoglycemia induced by massive dose of insulin degludec is persistent and prominent.

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