Persistent Hypoglycemia Induced by Long-acting Insulin Degludec

A 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464...

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Autores principales: Katakura, Yukino, Tatsumi, Fuminori, Kusano, Takashi, Shimoda, Masashi, Kohara, Kenji, Kimura, Tomohiko, Obata, Atsushi, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987256/
https://www.ncbi.nlm.nih.gov/pubmed/34483209
http://dx.doi.org/10.2169/internalmedicine.7915-21
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author Katakura, Yukino
Tatsumi, Fuminori
Kusano, Takashi
Shimoda, Masashi
Kohara, Kenji
Kimura, Tomohiko
Obata, Atsushi
Nakanishi, Shuhei
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
author_facet Katakura, Yukino
Tatsumi, Fuminori
Kusano, Takashi
Shimoda, Masashi
Kohara, Kenji
Kimura, Tomohiko
Obata, Atsushi
Nakanishi, Shuhei
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
author_sort Katakura, Yukino
collection PubMed
description A 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464 g. It took over three weeks for exogenous insulin to be almost undetectable. While degludec binds to albumin and exerts glucose-lowering effects for a long time, the above-mentioned period of three weeks was consistent with the half-life of albumin. Hypoglycemia induced by massive dose of insulin degludec is persistent and prominent.
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spelling pubmed-89872562022-04-26 Persistent Hypoglycemia Induced by Long-acting Insulin Degludec Katakura, Yukino Tatsumi, Fuminori Kusano, Takashi Shimoda, Masashi Kohara, Kenji Kimura, Tomohiko Obata, Atsushi Nakanishi, Shuhei Mune, Tomoatsu Kaku, Kohei Kaneto, Hideaki Intern Med Case Report A 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464 g. It took over three weeks for exogenous insulin to be almost undetectable. While degludec binds to albumin and exerts glucose-lowering effects for a long time, the above-mentioned period of three weeks was consistent with the half-life of albumin. Hypoglycemia induced by massive dose of insulin degludec is persistent and prominent. The Japanese Society of Internal Medicine 2021-09-04 2022-03-15 /pmc/articles/PMC8987256/ /pubmed/34483209 http://dx.doi.org/10.2169/internalmedicine.7915-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Katakura, Yukino
Tatsumi, Fuminori
Kusano, Takashi
Shimoda, Masashi
Kohara, Kenji
Kimura, Tomohiko
Obata, Atsushi
Nakanishi, Shuhei
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
title Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
title_full Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
title_fullStr Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
title_full_unstemmed Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
title_short Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
title_sort persistent hypoglycemia induced by long-acting insulin degludec
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987256/
https://www.ncbi.nlm.nih.gov/pubmed/34483209
http://dx.doi.org/10.2169/internalmedicine.7915-21
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