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Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia

Classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common primary adrenal insufficiency in children, involving cortisol deficiency, hyperandrogenism, and cardiometabolic risk. Prior studies have reported that youth with classical CAH have a higher prevalence...

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Autores principales: Kim, Mimi S., Fraga, Nicole R., Minaeian, Nare, Geffner, Mitchell E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987274/
https://www.ncbi.nlm.nih.gov/pubmed/35399922
http://dx.doi.org/10.3389/fendo.2022.848274
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author Kim, Mimi S.
Fraga, Nicole R.
Minaeian, Nare
Geffner, Mitchell E.
author_facet Kim, Mimi S.
Fraga, Nicole R.
Minaeian, Nare
Geffner, Mitchell E.
author_sort Kim, Mimi S.
collection PubMed
description Classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common primary adrenal insufficiency in children, involving cortisol deficiency, hyperandrogenism, and cardiometabolic risk. Prior studies have reported that youth with classical CAH have a higher prevalence of the components of metabolic syndrome: obesity, hypertension, elevated fasting blood glucose, and dyslipidemia. Yet, the incidence of the complete metabolic syndrome itself in children and adolescents with CAH is relatively rare. Traditional cardiometabolic risk factors can surface early in children with classical CAH, and continue to present and evolve over the lifetime, although it is only recently that reports of Type 2 diabetes and adverse cardiac events have begun to surface in adults affected by this condition. The pathophysiology underlying the increased prevalence of cardiometabolic risk factors in patients with CAH is not well-understood, with disease treatments and androgen excess having been studied to date. The aim of this review is to evaluate the recent literature on traditional cardiometabolic risk factors in youth with classical CAH, and to consider non-traditional risk factors/biomarkers for subclinical atherosclerosis, inflammation, and insulin resistance. A better understanding of these traditional and non-traditional risk factors in youth with CAH could help guide treatment options and prevent the onset of metabolic syndrome in adulthood, reducing overall patient morbidity.
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spelling pubmed-89872742022-04-08 Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia Kim, Mimi S. Fraga, Nicole R. Minaeian, Nare Geffner, Mitchell E. Front Endocrinol (Lausanne) Endocrinology Classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common primary adrenal insufficiency in children, involving cortisol deficiency, hyperandrogenism, and cardiometabolic risk. Prior studies have reported that youth with classical CAH have a higher prevalence of the components of metabolic syndrome: obesity, hypertension, elevated fasting blood glucose, and dyslipidemia. Yet, the incidence of the complete metabolic syndrome itself in children and adolescents with CAH is relatively rare. Traditional cardiometabolic risk factors can surface early in children with classical CAH, and continue to present and evolve over the lifetime, although it is only recently that reports of Type 2 diabetes and adverse cardiac events have begun to surface in adults affected by this condition. The pathophysiology underlying the increased prevalence of cardiometabolic risk factors in patients with CAH is not well-understood, with disease treatments and androgen excess having been studied to date. The aim of this review is to evaluate the recent literature on traditional cardiometabolic risk factors in youth with classical CAH, and to consider non-traditional risk factors/biomarkers for subclinical atherosclerosis, inflammation, and insulin resistance. A better understanding of these traditional and non-traditional risk factors in youth with CAH could help guide treatment options and prevent the onset of metabolic syndrome in adulthood, reducing overall patient morbidity. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC8987274/ /pubmed/35399922 http://dx.doi.org/10.3389/fendo.2022.848274 Text en Copyright © 2022 Kim, Fraga, Minaeian and Geffner https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Kim, Mimi S.
Fraga, Nicole R.
Minaeian, Nare
Geffner, Mitchell E.
Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
title Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
title_full Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
title_fullStr Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
title_full_unstemmed Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
title_short Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
title_sort components of metabolic syndrome in youth with classical congenital adrenal hyperplasia
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987274/
https://www.ncbi.nlm.nih.gov/pubmed/35399922
http://dx.doi.org/10.3389/fendo.2022.848274
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