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ENO1 and Cancer

α-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit se...

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Autores principales: Huang, Chen Kai, Sun, Ying, Lv, Lei, Ping, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987341/
https://www.ncbi.nlm.nih.gov/pubmed/35434271
http://dx.doi.org/10.1016/j.omto.2021.12.026
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author Huang, Chen Kai
Sun, Ying
Lv, Lei
Ping, Yong
author_facet Huang, Chen Kai
Sun, Ying
Lv, Lei
Ping, Yong
author_sort Huang, Chen Kai
collection PubMed
description α-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit seven out of ten “hallmarks of cancer.” ENO1's glycolytic function deregulates cellular energetic, sustains tumor proliferation, and inhibits cancer cell apoptosis. Moreover, ENO1 evades growth suppressors and helps tumors to avoid immune destruction. Besides, ENO1 “moonlights” on the cell surface and acts as a plasminogen receptor, promoting cancer invasion and metastasis by inducing angiogenesis. Overexpression of ENO1 on a myriad of cancer types together with its localization on the tumor surface makes it a great prognostic and diagnostic cancer biomarker as well as an accessible oncotherapeutic target. This review summarizes the up-to-date knowledge about the relationship between ENO1 and cancer, examines ENO1's potential as a cancer biomarker, and discusses ENO1's role in novel onco-immunotherapeutic strategies.
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spelling pubmed-89873412022-04-15 ENO1 and Cancer Huang, Chen Kai Sun, Ying Lv, Lei Ping, Yong Mol Ther Oncolytics Review α-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit seven out of ten “hallmarks of cancer.” ENO1's glycolytic function deregulates cellular energetic, sustains tumor proliferation, and inhibits cancer cell apoptosis. Moreover, ENO1 evades growth suppressors and helps tumors to avoid immune destruction. Besides, ENO1 “moonlights” on the cell surface and acts as a plasminogen receptor, promoting cancer invasion and metastasis by inducing angiogenesis. Overexpression of ENO1 on a myriad of cancer types together with its localization on the tumor surface makes it a great prognostic and diagnostic cancer biomarker as well as an accessible oncotherapeutic target. This review summarizes the up-to-date knowledge about the relationship between ENO1 and cancer, examines ENO1's potential as a cancer biomarker, and discusses ENO1's role in novel onco-immunotherapeutic strategies. American Society of Gene & Cell Therapy 2022-01-03 /pmc/articles/PMC8987341/ /pubmed/35434271 http://dx.doi.org/10.1016/j.omto.2021.12.026 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Chen Kai
Sun, Ying
Lv, Lei
Ping, Yong
ENO1 and Cancer
title ENO1 and Cancer
title_full ENO1 and Cancer
title_fullStr ENO1 and Cancer
title_full_unstemmed ENO1 and Cancer
title_short ENO1 and Cancer
title_sort eno1 and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987341/
https://www.ncbi.nlm.nih.gov/pubmed/35434271
http://dx.doi.org/10.1016/j.omto.2021.12.026
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