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Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias
Total antioxidant activity status (TAS) represents the body's response to oxidative stress, important in the pathogenic assessment of oxidations. Aim: To determine TAS variations in young subjects, with non-lesional cardiac arrhythmias, with/without dyslipidemia and to assess the risk of lipid...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medical University Publishing House Craiova
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987465/ https://www.ncbi.nlm.nih.gov/pubmed/35444827 http://dx.doi.org/10.12865/CHSJ.47.04.12 |
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author | BEZNĂ, MARIA CRISTINA PISOSCHI, CĂTĂLINA BEZNĂ, MARINELA DĂNOIU, SUZANA NEGROIU, CRISTINA-ELENA MELINTE, PETRU RĂZVAN |
author_facet | BEZNĂ, MARIA CRISTINA PISOSCHI, CĂTĂLINA BEZNĂ, MARINELA DĂNOIU, SUZANA NEGROIU, CRISTINA-ELENA MELINTE, PETRU RĂZVAN |
author_sort | BEZNĂ, MARIA CRISTINA |
collection | PubMed |
description | Total antioxidant activity status (TAS) represents the body's response to oxidative stress, important in the pathogenic assessment of oxidations. Aim: To determine TAS variations in young subjects, with non-lesional cardiac arrhythmias, with/without dyslipidemia and to assess the risk of lipid oxidation. Patients and methods: The research was performed on 120 young subjects (mean age 33 years), with various types of cardiac arrhythmias, on normal heart, without co-existing lesions. Subjects were divided into 3 groups (40 persons). The first 2 groups included subjects with cardiac arrhythmias. Group I also associated dyslipidemia; group II, without dyslipidemia and group III: control. Determination of TAS values was performed using ABTS (2-azino-di-3-ethylbenzthiazoline sulfonate) colorimetic method. Results were statistically processed. Results: TAS values were decreased in all patients with cardiac arrhythmias, representing 52-54% of the values of healthy controls, the data being highly statistically significant. The variation of TAS decrease by types of arrhythmias was thus found in patients with arrhythmias and associated dyslipidemia and, respectively, without dyslipidemia, compared to controls. The deficit of antioxidant activity, between 48%-46% triggers electrochemical processes with implications in arrhythmogenesis and lipid oxidation. Coffee and vegetables-rich diet have antioxidant effect, reducing TAS deficiency. Conclusions: 1. TAS was decreased in all subjects with non-lesional arrhythmias. The study showed decreasing TAS level at 52-54% in patients with arrhythmias, with/without dyslipidemia, compared to controls. 2. TAS deficiency was associated with various types of dysrhythmias, ranging from 62% to 33%. 3. Decreased TAS also triggers lipid oxidation, as risk factor for early atherosclerotic lesions. |
format | Online Article Text |
id | pubmed-8987465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Medical University Publishing House Craiova |
record_format | MEDLINE/PubMed |
spelling | pubmed-89874652022-04-19 Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias BEZNĂ, MARIA CRISTINA PISOSCHI, CĂTĂLINA BEZNĂ, MARINELA DĂNOIU, SUZANA NEGROIU, CRISTINA-ELENA MELINTE, PETRU RĂZVAN Curr Health Sci J Original Paper Total antioxidant activity status (TAS) represents the body's response to oxidative stress, important in the pathogenic assessment of oxidations. Aim: To determine TAS variations in young subjects, with non-lesional cardiac arrhythmias, with/without dyslipidemia and to assess the risk of lipid oxidation. Patients and methods: The research was performed on 120 young subjects (mean age 33 years), with various types of cardiac arrhythmias, on normal heart, without co-existing lesions. Subjects were divided into 3 groups (40 persons). The first 2 groups included subjects with cardiac arrhythmias. Group I also associated dyslipidemia; group II, without dyslipidemia and group III: control. Determination of TAS values was performed using ABTS (2-azino-di-3-ethylbenzthiazoline sulfonate) colorimetic method. Results were statistically processed. Results: TAS values were decreased in all patients with cardiac arrhythmias, representing 52-54% of the values of healthy controls, the data being highly statistically significant. The variation of TAS decrease by types of arrhythmias was thus found in patients with arrhythmias and associated dyslipidemia and, respectively, without dyslipidemia, compared to controls. The deficit of antioxidant activity, between 48%-46% triggers electrochemical processes with implications in arrhythmogenesis and lipid oxidation. Coffee and vegetables-rich diet have antioxidant effect, reducing TAS deficiency. Conclusions: 1. TAS was decreased in all subjects with non-lesional arrhythmias. The study showed decreasing TAS level at 52-54% in patients with arrhythmias, with/without dyslipidemia, compared to controls. 2. TAS deficiency was associated with various types of dysrhythmias, ranging from 62% to 33%. 3. Decreased TAS also triggers lipid oxidation, as risk factor for early atherosclerotic lesions. Medical University Publishing House Craiova 2021 2021-12-31 /pmc/articles/PMC8987465/ /pubmed/35444827 http://dx.doi.org/10.12865/CHSJ.47.04.12 Text en Copyright © 2014, Medical University Publishing House Craiova https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. |
spellingShingle | Original Paper BEZNĂ, MARIA CRISTINA PISOSCHI, CĂTĂLINA BEZNĂ, MARINELA DĂNOIU, SUZANA NEGROIU, CRISTINA-ELENA MELINTE, PETRU RĂZVAN Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias |
title | Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias |
title_full | Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias |
title_fullStr | Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias |
title_full_unstemmed | Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias |
title_short | Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias |
title_sort | variation of total antioxidant activity in young people with non-lesional cardiac arrhythmias |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987465/ https://www.ncbi.nlm.nih.gov/pubmed/35444827 http://dx.doi.org/10.12865/CHSJ.47.04.12 |
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