The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression

Recently, the possibility of cross-kingdom gene expression regulation by miRNAs from other species (“xenomiRs”), specifically from plants, has acquired scientific meaning. Based on the one of oldest methods for dealing with inflammation via the use of cabbage leaf compresses, we investigated the eff...

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Autores principales: Kasarello, Kaja, Köhling, Iwona, Kosowska, Anna, Pucia, Katarzyna, Lukasik, Anna, Cudnoch-Jedrzejewska, Agnieszka, Paczek, Leszek, Zielenkiewicz, Urszula, Zielenkiewicz, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987499/
https://www.ncbi.nlm.nih.gov/pubmed/35401203
http://dx.doi.org/10.3389/fphar.2022.846830
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author Kasarello, Kaja
Köhling, Iwona
Kosowska, Anna
Pucia, Katarzyna
Lukasik, Anna
Cudnoch-Jedrzejewska, Agnieszka
Paczek, Leszek
Zielenkiewicz, Urszula
Zielenkiewicz, Piotr
author_facet Kasarello, Kaja
Köhling, Iwona
Kosowska, Anna
Pucia, Katarzyna
Lukasik, Anna
Cudnoch-Jedrzejewska, Agnieszka
Paczek, Leszek
Zielenkiewicz, Urszula
Zielenkiewicz, Piotr
author_sort Kasarello, Kaja
collection PubMed
description Recently, the possibility of cross-kingdom gene expression regulation by miRNAs from other species (“xenomiRs”), specifically from plants, has acquired scientific meaning. Based on the one of oldest methods for dealing with inflammation via the use of cabbage leaf compresses, we investigated the effects of Brassica oleracea derived miR172a on the potential human target gene encoding FAN (Factor Associated with Neutral Sphingomyelinase Activation) protein. In vitro experiments showed a decrease in FAN protein levels in both human and mouse cells transfected with bol-miRNA172a. As the FAN protein mediates inflammatory responses, the potential of miR172a to mitigate the inflammatory process was tested in a mouse model of rheumatoid arthritis. Animal studies showed the decreased oedema of inflamed paws in mouse with rheumatoid arthritis model induced after treatment with miR172a.
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spelling pubmed-89874992022-04-08 The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression Kasarello, Kaja Köhling, Iwona Kosowska, Anna Pucia, Katarzyna Lukasik, Anna Cudnoch-Jedrzejewska, Agnieszka Paczek, Leszek Zielenkiewicz, Urszula Zielenkiewicz, Piotr Front Pharmacol Pharmacology Recently, the possibility of cross-kingdom gene expression regulation by miRNAs from other species (“xenomiRs”), specifically from plants, has acquired scientific meaning. Based on the one of oldest methods for dealing with inflammation via the use of cabbage leaf compresses, we investigated the effects of Brassica oleracea derived miR172a on the potential human target gene encoding FAN (Factor Associated with Neutral Sphingomyelinase Activation) protein. In vitro experiments showed a decrease in FAN protein levels in both human and mouse cells transfected with bol-miRNA172a. As the FAN protein mediates inflammatory responses, the potential of miR172a to mitigate the inflammatory process was tested in a mouse model of rheumatoid arthritis. Animal studies showed the decreased oedema of inflamed paws in mouse with rheumatoid arthritis model induced after treatment with miR172a. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC8987499/ /pubmed/35401203 http://dx.doi.org/10.3389/fphar.2022.846830 Text en Copyright © 2022 Kasarello, Köhling, Kosowska, Pucia, Lukasik, Cudnoch-Jedrzejewska, Paczek, Zielenkiewicz and Zielenkiewicz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kasarello, Kaja
Köhling, Iwona
Kosowska, Anna
Pucia, Katarzyna
Lukasik, Anna
Cudnoch-Jedrzejewska, Agnieszka
Paczek, Leszek
Zielenkiewicz, Urszula
Zielenkiewicz, Piotr
The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
title The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
title_full The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
title_fullStr The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
title_full_unstemmed The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
title_short The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
title_sort anti-inflammatory effect of cabbage leaves explained by the influence of bol-mirna172a on fan expression
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987499/
https://www.ncbi.nlm.nih.gov/pubmed/35401203
http://dx.doi.org/10.3389/fphar.2022.846830
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