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Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2
The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a stru...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987587/ https://www.ncbi.nlm.nih.gov/pubmed/35401544 http://dx.doi.org/10.3389/fimmu.2022.824378 |
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| author | Taşlı, Neslihan Pakize Gönen, Zeynep Burçin Kırbaş, Oğuz Kaan Gökdemir, Nur Seda Bozkurt, Batuhan Turhan Bayrakcı, Buse Sağraç, Derya Taşkan, Ezgi Demir, Sevda Ekimci Gürcan, Nur Bayındır Bilgiç, Melike Bayrak, Ömer Faruk Yetişkin, Hazel Kaplan, Büşra Pavel, Shaikh Terkıs Islam Dinç, Gökçen Serhatlı, Müge Çakırca, Gamze Eken, Ahmet Aslan, Vedat Yay, Mehmet Karakukcu, Musa Unal, Ekrem Gül, Fethi Basaran, Kemal Erdem Ozkul, Yusuf Şahin, Fikrettin Jones, Olcay Y. Tekin, Şaban Özdarendeli, Aykut Cetin, Mustafa |
| author_facet | Taşlı, Neslihan Pakize Gönen, Zeynep Burçin Kırbaş, Oğuz Kaan Gökdemir, Nur Seda Bozkurt, Batuhan Turhan Bayrakcı, Buse Sağraç, Derya Taşkan, Ezgi Demir, Sevda Ekimci Gürcan, Nur Bayındır Bilgiç, Melike Bayrak, Ömer Faruk Yetişkin, Hazel Kaplan, Büşra Pavel, Shaikh Terkıs Islam Dinç, Gökçen Serhatlı, Müge Çakırca, Gamze Eken, Ahmet Aslan, Vedat Yay, Mehmet Karakukcu, Musa Unal, Ekrem Gül, Fethi Basaran, Kemal Erdem Ozkul, Yusuf Şahin, Fikrettin Jones, Olcay Y. Tekin, Şaban Özdarendeli, Aykut Cetin, Mustafa |
| author_sort | Taşlı, Neslihan Pakize |
| collection | PubMed |
| description | The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models. |
| format | Online Article Text |
| id | pubmed-8987587 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89875872022-04-08 Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 Taşlı, Neslihan Pakize Gönen, Zeynep Burçin Kırbaş, Oğuz Kaan Gökdemir, Nur Seda Bozkurt, Batuhan Turhan Bayrakcı, Buse Sağraç, Derya Taşkan, Ezgi Demir, Sevda Ekimci Gürcan, Nur Bayındır Bilgiç, Melike Bayrak, Ömer Faruk Yetişkin, Hazel Kaplan, Büşra Pavel, Shaikh Terkıs Islam Dinç, Gökçen Serhatlı, Müge Çakırca, Gamze Eken, Ahmet Aslan, Vedat Yay, Mehmet Karakukcu, Musa Unal, Ekrem Gül, Fethi Basaran, Kemal Erdem Ozkul, Yusuf Şahin, Fikrettin Jones, Olcay Y. Tekin, Şaban Özdarendeli, Aykut Cetin, Mustafa Front Immunol Immunology The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC8987587/ /pubmed/35401544 http://dx.doi.org/10.3389/fimmu.2022.824378 Text en Copyright © 2022 Taşlı, Gönen, Kırbaş, Gökdemir, Bozkurt, Bayrakcı, Sağraç, Taşkan, Demir, Ekimci Gürcan, Bayındır Bilgiç, Bayrak, Yetişkin, Kaplan, Pavel, Dinç, Serhatlı, Çakırca, Eken, Aslan, Yay, Karakukcu, Unal, Gül, Basaran, Ozkul, Şahin, Jones, Tekin, Özdarendeli and Cetin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Immunology Taşlı, Neslihan Pakize Gönen, Zeynep Burçin Kırbaş, Oğuz Kaan Gökdemir, Nur Seda Bozkurt, Batuhan Turhan Bayrakcı, Buse Sağraç, Derya Taşkan, Ezgi Demir, Sevda Ekimci Gürcan, Nur Bayındır Bilgiç, Melike Bayrak, Ömer Faruk Yetişkin, Hazel Kaplan, Büşra Pavel, Shaikh Terkıs Islam Dinç, Gökçen Serhatlı, Müge Çakırca, Gamze Eken, Ahmet Aslan, Vedat Yay, Mehmet Karakukcu, Musa Unal, Ekrem Gül, Fethi Basaran, Kemal Erdem Ozkul, Yusuf Şahin, Fikrettin Jones, Olcay Y. Tekin, Şaban Özdarendeli, Aykut Cetin, Mustafa Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 |
| title | Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 |
| title_full | Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 |
| title_fullStr | Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 |
| title_full_unstemmed | Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 |
| title_short | Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2 |
| title_sort | preclinical studies on convalescent human immune plasma-derived exosome: omics and antiviral properties to sars-cov-2 |
| topic | Immunology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987587/ https://www.ncbi.nlm.nih.gov/pubmed/35401544 http://dx.doi.org/10.3389/fimmu.2022.824378 |
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