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Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken
The Korat chicken (KR), developed in Thailand, is a slow-growing breed developed as an alternative breed for Thai chicken producers. The growing interest in slow-growing chicken meat, due to its unique taste, distinct texture, health benefits, and higher broiler welfare have led to higher market dem...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987610/ https://www.ncbi.nlm.nih.gov/pubmed/35395531 http://dx.doi.org/10.1016/j.psj.2022.101824 |
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author | Kaewsatuan, Pramin Poompramun, Chotima Kubota, Satoshi Yongsawatdigul, Jirawat Molee, Wittawat Uimari, Pekka Molee, Amonrat |
author_facet | Kaewsatuan, Pramin Poompramun, Chotima Kubota, Satoshi Yongsawatdigul, Jirawat Molee, Wittawat Uimari, Pekka Molee, Amonrat |
author_sort | Kaewsatuan, Pramin |
collection | PubMed |
description | The Korat chicken (KR), developed in Thailand, is a slow-growing breed developed as an alternative breed for Thai chicken producers. The growing interest in slow-growing chicken meat, due to its unique taste, distinct texture, health benefits, and higher broiler welfare have led to higher market demand for KR. However, its low feed efficiency (FE) has a significant negative impact on farm profitability. Understanding the molecular mechanism regulating FE allows for designing a suitable selection program and contributing to breeding more efficient chicken for poultry production. Thus, the objective of our study was to investigate the proteome differences and possible pathways associated with FE in male KR using a label-free quantitative proteomic approach. Seventy-five KR males were individually evaluated for FE, and duodenum samples from 6 animals (3 high-FE and 3 low-FE chickens) were collected at 10 wk of age for differential abundant proteins (DAPs), protein networks, functional enrichment, and pathway analyses. In this study, we found 40 DAPs significantly associated with FE pathways, including glycolysis/gluconeogenesis, peroxisome, oxidative phosphorylation, tight junction, and cysteine and methionine metabolism. Thus, variations in observed DAPs or genes related to DAPs could be interesting biomarker candidates for selection for higher feed utilization efficiency in chicken. |
format | Online Article Text |
id | pubmed-8987610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89876102022-04-08 Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken Kaewsatuan, Pramin Poompramun, Chotima Kubota, Satoshi Yongsawatdigul, Jirawat Molee, Wittawat Uimari, Pekka Molee, Amonrat Poult Sci GENETICS AND MOLECULAR BIOLOGY The Korat chicken (KR), developed in Thailand, is a slow-growing breed developed as an alternative breed for Thai chicken producers. The growing interest in slow-growing chicken meat, due to its unique taste, distinct texture, health benefits, and higher broiler welfare have led to higher market demand for KR. However, its low feed efficiency (FE) has a significant negative impact on farm profitability. Understanding the molecular mechanism regulating FE allows for designing a suitable selection program and contributing to breeding more efficient chicken for poultry production. Thus, the objective of our study was to investigate the proteome differences and possible pathways associated with FE in male KR using a label-free quantitative proteomic approach. Seventy-five KR males were individually evaluated for FE, and duodenum samples from 6 animals (3 high-FE and 3 low-FE chickens) were collected at 10 wk of age for differential abundant proteins (DAPs), protein networks, functional enrichment, and pathway analyses. In this study, we found 40 DAPs significantly associated with FE pathways, including glycolysis/gluconeogenesis, peroxisome, oxidative phosphorylation, tight junction, and cysteine and methionine metabolism. Thus, variations in observed DAPs or genes related to DAPs could be interesting biomarker candidates for selection for higher feed utilization efficiency in chicken. Elsevier 2022-03-08 /pmc/articles/PMC8987610/ /pubmed/35395531 http://dx.doi.org/10.1016/j.psj.2022.101824 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | GENETICS AND MOLECULAR BIOLOGY Kaewsatuan, Pramin Poompramun, Chotima Kubota, Satoshi Yongsawatdigul, Jirawat Molee, Wittawat Uimari, Pekka Molee, Amonrat Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
title | Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
title_full | Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
title_fullStr | Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
title_full_unstemmed | Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
title_short | Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
title_sort | comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken |
topic | GENETICS AND MOLECULAR BIOLOGY |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987610/ https://www.ncbi.nlm.nih.gov/pubmed/35395531 http://dx.doi.org/10.1016/j.psj.2022.101824 |
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