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Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis. The BBB is composed of endothelial cells, basement membrane, pericytes, and ast...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Diabetes Association
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987684/ https://www.ncbi.nlm.nih.gov/pubmed/35299293 http://dx.doi.org/10.4093/dmj.2021.0146 |
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author | Li, Xiaolong Cai, Yan Zhang, Zuo Zhou, Jiyin |
author_facet | Li, Xiaolong Cai, Yan Zhang, Zuo Zhou, Jiyin |
author_sort | Li, Xiaolong |
collection | PubMed |
description | As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis. The BBB is composed of endothelial cells, basement membrane, pericytes, and astrocytic end feet. BBB impairment is a distinguishing and pathogenic factor in diabetic encephalopathy. Diabetes causes leakage of the BBB through downregulation of tight junction proteins, resulting in impaired functioning of endothelial cells, pericytes, astrocytes, microglia, nerve/glial antigen 2-glia, and oligodendrocytes. However, the temporal regulation, mechanisms of molecular and signaling pathways, and consequences of BBB impairment in diabetes are not well understood. Consequently, the efficacy of therapies diabetes targeting BBB leakage still lags behind the requirements. This review summarizes the recent research on the effects of diabetes on BBB composition and the potential roles of glial and vascular cells as therapeutic targets for BBB disruption in diabetic encephalopathy. |
format | Online Article Text |
id | pubmed-8987684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-89876842022-04-13 Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes Li, Xiaolong Cai, Yan Zhang, Zuo Zhou, Jiyin Diabetes Metab J Review As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis. The BBB is composed of endothelial cells, basement membrane, pericytes, and astrocytic end feet. BBB impairment is a distinguishing and pathogenic factor in diabetic encephalopathy. Diabetes causes leakage of the BBB through downregulation of tight junction proteins, resulting in impaired functioning of endothelial cells, pericytes, astrocytes, microglia, nerve/glial antigen 2-glia, and oligodendrocytes. However, the temporal regulation, mechanisms of molecular and signaling pathways, and consequences of BBB impairment in diabetes are not well understood. Consequently, the efficacy of therapies diabetes targeting BBB leakage still lags behind the requirements. This review summarizes the recent research on the effects of diabetes on BBB composition and the potential roles of glial and vascular cells as therapeutic targets for BBB disruption in diabetic encephalopathy. Korean Diabetes Association 2022-03 2022-03-18 /pmc/articles/PMC8987684/ /pubmed/35299293 http://dx.doi.org/10.4093/dmj.2021.0146 Text en Copyright © 2022 Korean Diabetes Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Li, Xiaolong Cai, Yan Zhang, Zuo Zhou, Jiyin Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes |
title | Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes |
title_full | Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes |
title_fullStr | Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes |
title_full_unstemmed | Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes |
title_short | Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes |
title_sort | glial and vascular cell regulation of the blood-brain barrier in diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987684/ https://www.ncbi.nlm.nih.gov/pubmed/35299293 http://dx.doi.org/10.4093/dmj.2021.0146 |
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