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Anxiety and amygdala connectivity during movie-watching

Rodent and human studies have implicated an amygdala-prefrontal circuit during threat processing. One possibility is that while amygdala activity underlies core features of anxiety (e.g. detection of salient information), prefrontal cortices (i.e. dorsomedial prefrontal/anterior cingulate cortex) en...

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Detalles Bibliográficos
Autores principales: Kirk, Peter A., Robinson, Oliver J., Skipper, Jeremy I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987737/
https://www.ncbi.nlm.nih.gov/pubmed/35245529
http://dx.doi.org/10.1016/j.neuropsychologia.2022.108194
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author Kirk, Peter A.
Robinson, Oliver J.
Skipper, Jeremy I.
author_facet Kirk, Peter A.
Robinson, Oliver J.
Skipper, Jeremy I.
author_sort Kirk, Peter A.
collection PubMed
description Rodent and human studies have implicated an amygdala-prefrontal circuit during threat processing. One possibility is that while amygdala activity underlies core features of anxiety (e.g. detection of salient information), prefrontal cortices (i.e. dorsomedial prefrontal/anterior cingulate cortex) entrain its responsiveness. To date, this has been established in tightly controlled paradigms (predominantly using static face perception tasks) but has not been extended to more naturalistic settings. Consequently, using ‘movie fMRI’—in which participants watch ecologically-rich movie stimuli rather than constrained cognitive tasks—we sought to test whether individual differences in anxiety correlate with the degree of face-dependent amygdala-prefrontal coupling in two independent samples. Analyses suggested increased face-dependent superior parietal activation and decreased speech-dependent auditory cortex activation as a function of anxiety. However, we failed to find evidence for anxiety-dependent connectivity, neither in our stimulus-dependent or -independent analyses. Our findings suggest that work using experimentally constrained tasks may not replicate in more ecologically valid settings and, moreover, highlight the importance of testing the generalizability of neuroimaging findings outside of the original context.
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spelling pubmed-89877372022-05-17 Anxiety and amygdala connectivity during movie-watching Kirk, Peter A. Robinson, Oliver J. Skipper, Jeremy I. Neuropsychologia Article Rodent and human studies have implicated an amygdala-prefrontal circuit during threat processing. One possibility is that while amygdala activity underlies core features of anxiety (e.g. detection of salient information), prefrontal cortices (i.e. dorsomedial prefrontal/anterior cingulate cortex) entrain its responsiveness. To date, this has been established in tightly controlled paradigms (predominantly using static face perception tasks) but has not been extended to more naturalistic settings. Consequently, using ‘movie fMRI’—in which participants watch ecologically-rich movie stimuli rather than constrained cognitive tasks—we sought to test whether individual differences in anxiety correlate with the degree of face-dependent amygdala-prefrontal coupling in two independent samples. Analyses suggested increased face-dependent superior parietal activation and decreased speech-dependent auditory cortex activation as a function of anxiety. However, we failed to find evidence for anxiety-dependent connectivity, neither in our stimulus-dependent or -independent analyses. Our findings suggest that work using experimentally constrained tasks may not replicate in more ecologically valid settings and, moreover, highlight the importance of testing the generalizability of neuroimaging findings outside of the original context. Pergamon Press 2022-05-03 /pmc/articles/PMC8987737/ /pubmed/35245529 http://dx.doi.org/10.1016/j.neuropsychologia.2022.108194 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kirk, Peter A.
Robinson, Oliver J.
Skipper, Jeremy I.
Anxiety and amygdala connectivity during movie-watching
title Anxiety and amygdala connectivity during movie-watching
title_full Anxiety and amygdala connectivity during movie-watching
title_fullStr Anxiety and amygdala connectivity during movie-watching
title_full_unstemmed Anxiety and amygdala connectivity during movie-watching
title_short Anxiety and amygdala connectivity during movie-watching
title_sort anxiety and amygdala connectivity during movie-watching
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987737/
https://www.ncbi.nlm.nih.gov/pubmed/35245529
http://dx.doi.org/10.1016/j.neuropsychologia.2022.108194
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