AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells

BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes. Here, we determined the anti-HCC efficacy of AZD5153, a potent...

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Detalles Bibliográficos
Autores principales: Lin, Cho-Hao, Kuo, Jimmy Chun-Tien, Li, Ding, Koenig, Aaron B., Pan, Alexander, Yan, Pearlly, Bai, Xue-Feng, Lee, Robert J., Ghoshal, Kalpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987780/
https://www.ncbi.nlm.nih.gov/pubmed/35399501
http://dx.doi.org/10.3389/fcell.2022.853652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987780/
https://www.ncbi.nlm.nih.gov/pubmed/35399501
http://dx.doi.org/10.3389/fcell.2022.853652

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