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Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients
BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation status is related to the prognosis and immune microenvironment of glioma. Long non-coding ribonucleic acids (lncRNAs) interact with microRNAs (miRNAs), and play roles in the competitive endogenous RNA (ceRNA) network and tumor progression. METHO...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987889/ https://www.ncbi.nlm.nih.gov/pubmed/35402587 http://dx.doi.org/10.21037/atm-21-6983 |
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author | Wang, Wen-Jie Lu, Yu-Jie Li, Ying Tang, Jie-Qing Wang, Han Song, Wei Wang, Jing-Jing Huang, Yue-Qing Wang, Ying Lian, Lian |
author_facet | Wang, Wen-Jie Lu, Yu-Jie Li, Ying Tang, Jie-Qing Wang, Han Song, Wei Wang, Jing-Jing Huang, Yue-Qing Wang, Ying Lian, Lian |
author_sort | Wang, Wen-Jie |
collection | PubMed |
description | BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation status is related to the prognosis and immune microenvironment of glioma. Long non-coding ribonucleic acids (lncRNAs) interact with microRNAs (miRNAs), and play roles in the competitive endogenous RNA (ceRNA) network and tumor progression. METHODS: Data on low-grade glioma (LGG) IDH1 mutation was acquired from The Cancer Genome Atlas (TCGA). An empirical analysis of differential gene expression was conducted to identify differentially expressed mRNAs (DEmRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed lncRNAs (DElncRNAs). Survival-associated genes were identified by a univariate Cox regression analysis. An enrichment analysis was conducted to explore the gene ontology and pathways of the DEmRNAs. RESULTS: Eighty-eight DEIDH1mRNAs, 88 DEIDH1lncRNAs, and 6 DEIDH1miRNAs were identified to construct a ceRNA network of LGG patients. Validated by Chinese Glioma Genome Atlas and our LGG patients of gene expression and survival, and the colorectal neoplasia differentially expressed (CRNDE), HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1)/miRNA-206a/hepatocyte nuclear factor 4 (HNF4G) axis was determined. CONCLUSIONS: We established a ceRNA network by integrating the different IDH1 mutation statuses of LGG patients, and identified HNF4G, CRNDE, and HOTAIRM1 as genes related to the prognosis of and immune infiltration in LGG patients. Our findings suggest that these genes may be targets for LGG treatment, especially for patients with the wild-type IDH1 gene variants. |
format | Online Article Text |
id | pubmed-8987889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-89878892022-04-08 Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients Wang, Wen-Jie Lu, Yu-Jie Li, Ying Tang, Jie-Qing Wang, Han Song, Wei Wang, Jing-Jing Huang, Yue-Qing Wang, Ying Lian, Lian Ann Transl Med Original Article BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation status is related to the prognosis and immune microenvironment of glioma. Long non-coding ribonucleic acids (lncRNAs) interact with microRNAs (miRNAs), and play roles in the competitive endogenous RNA (ceRNA) network and tumor progression. METHODS: Data on low-grade glioma (LGG) IDH1 mutation was acquired from The Cancer Genome Atlas (TCGA). An empirical analysis of differential gene expression was conducted to identify differentially expressed mRNAs (DEmRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed lncRNAs (DElncRNAs). Survival-associated genes were identified by a univariate Cox regression analysis. An enrichment analysis was conducted to explore the gene ontology and pathways of the DEmRNAs. RESULTS: Eighty-eight DEIDH1mRNAs, 88 DEIDH1lncRNAs, and 6 DEIDH1miRNAs were identified to construct a ceRNA network of LGG patients. Validated by Chinese Glioma Genome Atlas and our LGG patients of gene expression and survival, and the colorectal neoplasia differentially expressed (CRNDE), HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1)/miRNA-206a/hepatocyte nuclear factor 4 (HNF4G) axis was determined. CONCLUSIONS: We established a ceRNA network by integrating the different IDH1 mutation statuses of LGG patients, and identified HNF4G, CRNDE, and HOTAIRM1 as genes related to the prognosis of and immune infiltration in LGG patients. Our findings suggest that these genes may be targets for LGG treatment, especially for patients with the wild-type IDH1 gene variants. AME Publishing Company 2022-03 /pmc/articles/PMC8987889/ /pubmed/35402587 http://dx.doi.org/10.21037/atm-21-6983 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Wang, Wen-Jie Lu, Yu-Jie Li, Ying Tang, Jie-Qing Wang, Han Song, Wei Wang, Jing-Jing Huang, Yue-Qing Wang, Ying Lian, Lian Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients |
title | Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients |
title_full | Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients |
title_fullStr | Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients |
title_full_unstemmed | Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients |
title_short | Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients |
title_sort | construction of cerna networks with different types of idh1 mutation status in low-grade glioma patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987889/ https://www.ncbi.nlm.nih.gov/pubmed/35402587 http://dx.doi.org/10.21037/atm-21-6983 |
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