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Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants

Hepatocyte nuclear factor 1A (HNF-1A) is a transcription factor expressed in several embryonic and adult tissues, modulating the expression of numerous target genes. Pathogenic variants in the HNF1A gene are known to cause maturity-onset diabetes of the young 3 (MODY3 or HNF1A MODY), a disease chara...

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Detalles Bibliográficos
Autores principales:	Kind, Laura, Raasakka, Arne, Molnes, Janne, Aukrust, Ingvild, Bjørkhaug, Lise, Njølstad, Pål Rasmus, Kursula, Petri, Arnesen, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988010/ https://www.ncbi.nlm.nih.gov/pubmed/35257744 http://dx.doi.org/10.1016/j.jbc.2022.101803

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