Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions

Although 3D cell culture models are considered to reflect the physiological microenvironment and exhibit high concordance with in vivo conditions, one disadvantage has been that cell proliferation is slower in 3D culture as compared to 2D culture. However, the signaling differences that lead to this...

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Detalles Bibliográficos
Autores principales: Aihara, Ayako, Iwawaki, Takumi, Abe-Fukasawa, Natsuki, Otsuka, Keiichiro, Saruhashi, Koichiro, Mikashima, Takumi, Nishino, Taito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988011/
https://www.ncbi.nlm.nih.gov/pubmed/35231442
http://dx.doi.org/10.1016/j.jbc.2022.101779

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