Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor

Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically alleviate the volume of brain infarct and restore...

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Detalles Bibliográficos
Autores principales: Qi, Xin, Lu, Jian-Fei, Huang, Zi-Yue, Liu, Yi-Jun, Cai, Lu-Bing, Wen, Xin-Lan, Song, Xing-Lei, Xiong, Jian, Sun, Pei-Yi, Zhang, Hao, Zhang, Ting-Ting, Zhao, Xuan, Jiang, Qin, Li, Ying, Krishtal, Oleg, Hou, Leng-Chen, Zhu, Michael X., Xu, Tian-Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988055/
https://www.ncbi.nlm.nih.gov/pubmed/35401212
http://dx.doi.org/10.3389/fphar.2022.849498

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