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Re-Expression of ERα and AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition

DNA methylation, catalyzed by DNA methyltransferase (DNMT), is a well-characterized epigenetic modification in cancer cells. In particular, promoter hypermethylation of AR and ESR1 results in loss of expression on Androgen Receptor (AR) and Estrogen Receptor (ER), respectively, and is associated wit...

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Detalles Bibliográficos
Autores principales:	Sharma, Vikas, Joshi, Jayadev, Yeh, I-Ju, Doughman, YongQiu, Blankenberg, Daniel, Wald, David, Montano, Monica M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988137/ https://www.ncbi.nlm.nih.gov/pubmed/35402240 http://dx.doi.org/10.3389/fonc.2022.824594

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