Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells

Small‐Cell Lung Cancer (SCLC) is an aggressive neuroendocrine malignancy with a poor prognosis. Here, we focus on the neuroendocrine SCLC subtypes, SCLC‐A and SCLC‐N, whose transcription addiction was driven by ASCL1 and NEUROD1 transcription factors which target E‐box motifs to activate up to 40% o...

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Detalles Bibliográficos
Autores principales: Costanzo, Federico, Martínez Diez, Marta, Santamaría Nuñez, Gema, Díaz‐Hernandéz, Juan Ignacio, Genes Robles, Carlos Mario, Díez Pérez, Javier, Compe, Emmanuel, Ricci, Romeo, Li, Tsai‐Kun, Coin, Frédéric, Martínez Leal, Juan Fernando, Garrido‐Martin, Eva Maria, Egly, Jean Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988166/
https://www.ncbi.nlm.nih.gov/pubmed/35263037
http://dx.doi.org/10.15252/emmm.202114841

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