AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous system (CNS), largely because of their restricted blood–brain b...

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Detalles Bibliográficos
Autores principales: Marino, Marika, Zhou, Lujia, Rincon, Melvin Y, Callaerts‐Vegh, Zsuzsanna, Verhaert, Jens, Wahis, Jérôme, Creemers, Eline, Yshii, Lidia, Wierda, Keimpe, Saito, Takashi, Marneffe, Catherine, Voytyuk, Iryna, Wouters, Yessica, Dewilde, Maarten, Duqué, Sandra I, Vincke, Cécile, Levites, Yona, Golde, Todd E, Saido, Takaomi C, Muyldermans, Serge, Liston, Adrian, De Strooper, Bart, Holt, Matthew G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988209/
https://www.ncbi.nlm.nih.gov/pubmed/35352880
http://dx.doi.org/10.15252/emmm.201809824

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