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First Principles Calculation of Protein–Protein Dimer Affinities of ALS-Associated SOD1 Mutants

Cu,Zn superoxide dismutase (SOD1) is a 32 kDa homodimer that converts toxic oxygen radicals in neurons to less harmful species. The dimerization of SOD1 is essential to the stability of the protein. Monomerization increases the likelihood of SOD1 misfolding into conformations associated with aggrega...

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Detalles Bibliográficos
Autores principales:	Hsueh, Shawn C. C., Nijland, Mark, Peng, Xubiao, Hilton, Benjamin, Plotkin, Steven S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988244/ https://www.ncbi.nlm.nih.gov/pubmed/35402516 http://dx.doi.org/10.3389/fmolb.2022.845013

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