Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury

BACKGROUND: Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Alveolar epithelial cells play a crucial role in lung fibrosis via epithelial-mesenchymal transition (EMT). Exosomes derived from mesenchymal stem cells own the beneficial properties to repair and r...

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Detalles Bibliográficos
Autores principales: Li, Yi, Shen, Zhufu, Jiang, Xiao, Wang, Yuanyuan, Yang, Zuozhang, Mao, Yuchi, Wu, Zhixian, Li, Gaofeng, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988379/
https://www.ncbi.nlm.nih.gov/pubmed/35392967
http://dx.doi.org/10.1186/s13046-022-02351-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988379/
https://www.ncbi.nlm.nih.gov/pubmed/35392967
http://dx.doi.org/10.1186/s13046-022-02351-z

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