Cargando…
Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant
PURPOSE: Despite advances in treatments for COVID-19, a subset of patients develop end stage lung disease, necessitating lung transplantation. However, COVID-19 ARDS often requires prolonged intubation with sedation and paralytics, resulting in profound deconditioning. As such, extracorporeal membra...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988582/ http://dx.doi.org/10.1016/j.healun.2022.01.309 |
_version_ | 1784682993541971968 |
---|---|
author | Pasupneti, S. Tulu, Z. Rao, V. MacArthur, J.W. Mooney, J.J. Dhillon, G.S. |
author_facet | Pasupneti, S. Tulu, Z. Rao, V. MacArthur, J.W. Mooney, J.J. Dhillon, G.S. |
author_sort | Pasupneti, S. |
collection | PubMed |
description | PURPOSE: Despite advances in treatments for COVID-19, a subset of patients develop end stage lung disease, necessitating lung transplantation. However, COVID-19 ARDS often requires prolonged intubation with sedation and paralytics, resulting in profound deconditioning. As such, extracorporeal membranous oxygenation (ECMO) is a useful bridge to transplant to allow for a wakeful state and facilitate rehab. This study compares outcomes among patients with COVID-19 and nonCOVID-19 lung disease placed on ECMO as a bridge to transplant. METHODS: All patients on veno-venous ECMO prior to lung transplantation at a single center from Jan 2020 - Oct 2021 were identified. Patient characteristics and post-transplant outcomes were abstracted for comparison. RESULTS: A total of 7 patients were identified in the COVID-19 (C) cohort and 11 in the nonCOVID-19 (NC) cohort. Age and LAS at transplant were similar (Table 1). As expected, total duration on ECMO was longer for C cohort patients (85.4 vs 14.5 days). Patients in the C cohort had longer ischemia times and more returns to the OR within 72 hours of transplant (71% vs 45%). Rates of hemodialysis within 30 days of transplant were lower in the C cohort (14% vs 18%). Further, C cohort patients had higher rates of detectable donor specific antibodies by IgG (71% vs 55%), though all were negative by C1q and compatible cross matches. While total and ICU lengths of stay were longer in the C cohort, this group had a shorter post-transplant hospital length of stay. Median time post-transplant was 212 days for the C cohort and 154 days for the NC cohort; survival was 100% for both groups at follow up. CONCLUSION: For patients with COVID-19 ARDS, ECMO is a useful bridge to transplant to mitigate complications associated with prolonged mechanical ventilation. These preliminary data suggest prolonged periods of ECMO pre-transplant do not result in significant adverse events post-transplant. Additional analyses of graft function and survival at 6 and 12 months are ongoing. |
format | Online Article Text |
id | pubmed-8988582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89885822022-04-11 Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant Pasupneti, S. Tulu, Z. Rao, V. MacArthur, J.W. Mooney, J.J. Dhillon, G.S. J Heart Lung Transplant (288) PURPOSE: Despite advances in treatments for COVID-19, a subset of patients develop end stage lung disease, necessitating lung transplantation. However, COVID-19 ARDS often requires prolonged intubation with sedation and paralytics, resulting in profound deconditioning. As such, extracorporeal membranous oxygenation (ECMO) is a useful bridge to transplant to allow for a wakeful state and facilitate rehab. This study compares outcomes among patients with COVID-19 and nonCOVID-19 lung disease placed on ECMO as a bridge to transplant. METHODS: All patients on veno-venous ECMO prior to lung transplantation at a single center from Jan 2020 - Oct 2021 were identified. Patient characteristics and post-transplant outcomes were abstracted for comparison. RESULTS: A total of 7 patients were identified in the COVID-19 (C) cohort and 11 in the nonCOVID-19 (NC) cohort. Age and LAS at transplant were similar (Table 1). As expected, total duration on ECMO was longer for C cohort patients (85.4 vs 14.5 days). Patients in the C cohort had longer ischemia times and more returns to the OR within 72 hours of transplant (71% vs 45%). Rates of hemodialysis within 30 days of transplant were lower in the C cohort (14% vs 18%). Further, C cohort patients had higher rates of detectable donor specific antibodies by IgG (71% vs 55%), though all were negative by C1q and compatible cross matches. While total and ICU lengths of stay were longer in the C cohort, this group had a shorter post-transplant hospital length of stay. Median time post-transplant was 212 days for the C cohort and 154 days for the NC cohort; survival was 100% for both groups at follow up. CONCLUSION: For patients with COVID-19 ARDS, ECMO is a useful bridge to transplant to mitigate complications associated with prolonged mechanical ventilation. These preliminary data suggest prolonged periods of ECMO pre-transplant do not result in significant adverse events post-transplant. Additional analyses of graft function and survival at 6 and 12 months are ongoing. Published by Elsevier Inc. 2022-04 2022-04-07 /pmc/articles/PMC8988582/ http://dx.doi.org/10.1016/j.healun.2022.01.309 Text en Copyright © 2022 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | (288) Pasupneti, S. Tulu, Z. Rao, V. MacArthur, J.W. Mooney, J.J. Dhillon, G.S. Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant |
title | Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant |
title_full | Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant |
title_fullStr | Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant |
title_full_unstemmed | Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant |
title_short | Comparing Outcomes of COVID-19 vs NonCOVID-19 Lung Transplant Recipients on ECMO as a Bridge to Transplant |
title_sort | comparing outcomes of covid-19 vs noncovid-19 lung transplant recipients on ecmo as a bridge to transplant |
topic | (288) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988582/ http://dx.doi.org/10.1016/j.healun.2022.01.309 |
work_keys_str_mv | AT pasupnetis comparingoutcomesofcovid19vsnoncovid19lungtransplantrecipientsonecmoasabridgetotransplant AT tuluz comparingoutcomesofcovid19vsnoncovid19lungtransplantrecipientsonecmoasabridgetotransplant AT raov comparingoutcomesofcovid19vsnoncovid19lungtransplantrecipientsonecmoasabridgetotransplant AT macarthurjw comparingoutcomesofcovid19vsnoncovid19lungtransplantrecipientsonecmoasabridgetotransplant AT mooneyjj comparingoutcomesofcovid19vsnoncovid19lungtransplantrecipientsonecmoasabridgetotransplant AT dhillongs comparingoutcomesofcovid19vsnoncovid19lungtransplantrecipientsonecmoasabridgetotransplant |