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Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
PURPOSE: Lung transplantation is a life saving treatment option for patients with COVID-19 ARDS. We aim to assess the short-term outcomes of patients who underwent lung transplantation for COVID ARDS. METHODS: This is a single-center retrospective cohort study of patients who underwent lung transpla...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988625/ http://dx.doi.org/10.1016/j.healun.2022.01.1336 |
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author | Nandavaram, S. Scheuble, V. Benninger, L. Chandrashekaran, S. |
author_facet | Nandavaram, S. Scheuble, V. Benninger, L. Chandrashekaran, S. |
author_sort | Nandavaram, S. |
collection | PubMed |
description | PURPOSE: Lung transplantation is a life saving treatment option for patients with COVID-19 ARDS. We aim to assess the short-term outcomes of patients who underwent lung transplantation for COVID ARDS. METHODS: This is a single-center retrospective cohort study of patients who underwent lung transplantation for COVID 19 ARDS between 7/1/2020 and 06/30/2021. Study was IRB-approved. Baseline demographic data, pre transplant variables, peri operative data and post transplant variables were extracted. Post-transplant graft function variables were followed until 09/30/2021. RESULTS: Twenty patients underwent lung transplantation alone, and one patient underwent lung kidney transplantation. Nineteen patients (90%) were ECMO bridge to transplant and twenty patients (95%) were on mechanical ventilator until the transplant. These patients were followed for a median of 234 days [IQR (188-339)]. Three patients (14%) completed a one-year follow-up. Eighteen patients (86%) completed six months follow-up. None of the patients required dialysis. At the end of the follow up period, all patients have good graft function and none of the patients are on supplemental oxygen. CONCLUSION: With careful selection, lung transplants can be performed with reasonable post-transplant outcomes in COVID 19 ARDS patients. However, these patients tend to have a prolonged post transplant hospital stay, a median of 48 days with IQR (28.5 - 73.5). 50% of patients had at least one return to operating room post transplant for hemothorax. |
format | Online Article Text |
id | pubmed-8988625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89886252022-04-11 Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS Nandavaram, S. Scheuble, V. Benninger, L. Chandrashekaran, S. J Heart Lung Transplant (1315) PURPOSE: Lung transplantation is a life saving treatment option for patients with COVID-19 ARDS. We aim to assess the short-term outcomes of patients who underwent lung transplantation for COVID ARDS. METHODS: This is a single-center retrospective cohort study of patients who underwent lung transplantation for COVID 19 ARDS between 7/1/2020 and 06/30/2021. Study was IRB-approved. Baseline demographic data, pre transplant variables, peri operative data and post transplant variables were extracted. Post-transplant graft function variables were followed until 09/30/2021. RESULTS: Twenty patients underwent lung transplantation alone, and one patient underwent lung kidney transplantation. Nineteen patients (90%) were ECMO bridge to transplant and twenty patients (95%) were on mechanical ventilator until the transplant. These patients were followed for a median of 234 days [IQR (188-339)]. Three patients (14%) completed a one-year follow-up. Eighteen patients (86%) completed six months follow-up. None of the patients required dialysis. At the end of the follow up period, all patients have good graft function and none of the patients are on supplemental oxygen. CONCLUSION: With careful selection, lung transplants can be performed with reasonable post-transplant outcomes in COVID 19 ARDS patients. However, these patients tend to have a prolonged post transplant hospital stay, a median of 48 days with IQR (28.5 - 73.5). 50% of patients had at least one return to operating room post transplant for hemothorax. Published by Elsevier Inc. 2022-04 2022-04-07 /pmc/articles/PMC8988625/ http://dx.doi.org/10.1016/j.healun.2022.01.1336 Text en Copyright © 2022 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | (1315) Nandavaram, S. Scheuble, V. Benninger, L. Chandrashekaran, S. Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS |
title | Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS |
title_full | Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS |
title_fullStr | Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS |
title_full_unstemmed | Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS |
title_short | Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS |
title_sort | short term outcomes of patients who underwent lung transplant for covid-19 ards |
topic | (1315) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988625/ http://dx.doi.org/10.1016/j.healun.2022.01.1336 |
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