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Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS

PURPOSE: Lung transplantation is a life saving treatment option for patients with COVID-19 ARDS. We aim to assess the short-term outcomes of patients who underwent lung transplantation for COVID ARDS. METHODS: This is a single-center retrospective cohort study of patients who underwent lung transpla...

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Autores principales: Nandavaram, S., Scheuble, V., Benninger, L., Chandrashekaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988625/
http://dx.doi.org/10.1016/j.healun.2022.01.1336
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author Nandavaram, S.
Scheuble, V.
Benninger, L.
Chandrashekaran, S.
author_facet Nandavaram, S.
Scheuble, V.
Benninger, L.
Chandrashekaran, S.
author_sort Nandavaram, S.
collection PubMed
description PURPOSE: Lung transplantation is a life saving treatment option for patients with COVID-19 ARDS. We aim to assess the short-term outcomes of patients who underwent lung transplantation for COVID ARDS. METHODS: This is a single-center retrospective cohort study of patients who underwent lung transplantation for COVID 19 ARDS between 7/1/2020 and 06/30/2021. Study was IRB-approved. Baseline demographic data, pre transplant variables, peri operative data and post transplant variables were extracted. Post-transplant graft function variables were followed until 09/30/2021. RESULTS: Twenty patients underwent lung transplantation alone, and one patient underwent lung kidney transplantation. Nineteen patients (90%) were ECMO bridge to transplant and twenty patients (95%) were on mechanical ventilator until the transplant. These patients were followed for a median of 234 days [IQR (188-339)]. Three patients (14%) completed a one-year follow-up. Eighteen patients (86%) completed six months follow-up. None of the patients required dialysis. At the end of the follow up period, all patients have good graft function and none of the patients are on supplemental oxygen. CONCLUSION: With careful selection, lung transplants can be performed with reasonable post-transplant outcomes in COVID 19 ARDS patients. However, these patients tend to have a prolonged post transplant hospital stay, a median of 48 days with IQR (28.5 - 73.5). 50% of patients had at least one return to operating room post transplant for hemothorax.
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spelling pubmed-89886252022-04-11 Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS Nandavaram, S. Scheuble, V. Benninger, L. Chandrashekaran, S. J Heart Lung Transplant (1315) PURPOSE: Lung transplantation is a life saving treatment option for patients with COVID-19 ARDS. We aim to assess the short-term outcomes of patients who underwent lung transplantation for COVID ARDS. METHODS: This is a single-center retrospective cohort study of patients who underwent lung transplantation for COVID 19 ARDS between 7/1/2020 and 06/30/2021. Study was IRB-approved. Baseline demographic data, pre transplant variables, peri operative data and post transplant variables were extracted. Post-transplant graft function variables were followed until 09/30/2021. RESULTS: Twenty patients underwent lung transplantation alone, and one patient underwent lung kidney transplantation. Nineteen patients (90%) were ECMO bridge to transplant and twenty patients (95%) were on mechanical ventilator until the transplant. These patients were followed for a median of 234 days [IQR (188-339)]. Three patients (14%) completed a one-year follow-up. Eighteen patients (86%) completed six months follow-up. None of the patients required dialysis. At the end of the follow up period, all patients have good graft function and none of the patients are on supplemental oxygen. CONCLUSION: With careful selection, lung transplants can be performed with reasonable post-transplant outcomes in COVID 19 ARDS patients. However, these patients tend to have a prolonged post transplant hospital stay, a median of 48 days with IQR (28.5 - 73.5). 50% of patients had at least one return to operating room post transplant for hemothorax. Published by Elsevier Inc. 2022-04 2022-04-07 /pmc/articles/PMC8988625/ http://dx.doi.org/10.1016/j.healun.2022.01.1336 Text en Copyright © 2022 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle (1315)
Nandavaram, S.
Scheuble, V.
Benninger, L.
Chandrashekaran, S.
Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
title Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
title_full Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
title_fullStr Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
title_full_unstemmed Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
title_short Short Term Outcomes of Patients Who Underwent Lung Transplant for COVID-19 ARDS
title_sort short term outcomes of patients who underwent lung transplant for covid-19 ards
topic (1315)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988625/
http://dx.doi.org/10.1016/j.healun.2022.01.1336
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