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Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of (13)C-Bicarbonate Incorporation

[Image: see text] Human phosphoribosylaminoimidazole carboxylase phosphoribosylaminoimdiazole succinocarboxamide synthetase (PAICS) is a dual activity enzyme catalyzing two consecutive reactions in de novo purine nucleotide synthesis. Crystallographic structures of recombinant human PAICS suggested...

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Detalles Bibliográficos
Autores principales:	Shon, Hyungjoo, Matveeva, Elena A., Jull, Ella C., Hu, Yijia, Coupet, Tiffany A., Lee, Young-Sam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988938/ https://www.ncbi.nlm.nih.gov/pubmed/35285625 http://dx.doi.org/10.1021/acs.biochem.1c00803

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