Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice

BACKGROUND: Pulmonary hypertension (PH) is a common complication of COPD, associated with increased mortality and morbidity. Intriguingly, pulmonary vascular alterations have been suggested to drive emphysema development. Previously, we identified inducible nitric oxide synthase (iNOS) as an essenti...

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Detalles Bibliográficos
Autores principales: Gredic, Marija, Wu, Cheng-Yu, Hadzic, Stefan, Pak, Oleg, Savai, Rajkumar, Kojonazarov, Baktybek, Doswada, Siddartha, Weiss, Astrid, Weigert, Andreas, Guenther, Andreas, Brandes, Ralf P., Schermuly, Ralph T., Grimminger, Friedrich, Seeger, Werner, Sommer, Natascha, Kraut, Simone, Weissmann, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989054/
https://www.ncbi.nlm.nih.gov/pubmed/34475225
http://dx.doi.org/10.1183/13993003.01153-2021

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