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Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study
BACKGROUND: Smoking or weight loss is a risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of TB development. ME...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989195/ https://www.ncbi.nlm.nih.gov/pubmed/35390038 http://dx.doi.org/10.1371/journal.pone.0266262 |
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author | Kim, Seung Hoon Park, Yong-Moon Han, Kyungdo Ko, Seung Hyun Kim, Shin Young Song, So Hyang Kim, Chi Hong Hur, Kyu Yeon Kim, Sung Kyoung |
author_facet | Kim, Seung Hoon Park, Yong-Moon Han, Kyungdo Ko, Seung Hyun Kim, Shin Young Song, So Hyang Kim, Chi Hong Hur, Kyu Yeon Kim, Sung Kyoung |
author_sort | Kim, Seung Hoon |
collection | PubMed |
description | BACKGROUND: Smoking or weight loss is a risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of TB development. METHODS: We conducted a population-based cohort study using the national database in Republic of Korea. Of the 10,490,491 subjects who underwent health check-up in 2009, we enrolled 9,953,124 subjects without a previous TB history and followed them until 2017. We divided all study participants into the following three groups: never, former, and current smokers. The primary endpoint was newly developed TB. RESULTS: Among 9,953,124 subjects analyzed, 5,922,845 (59.5%) were never smokers, 1,428,209 (14.4%) were former smokers, and 2,602,080 (26.1%) were current smokers. The risk of TB development was significantly higher in current smokers than in never smokers (adjusted hazard ratio (aHR) 1.158; 95% confidence interval [CI] 1.131–1.186). Among current smokers, individuals who stopped smoking and maintained weight after baseline evaluation had a significantly lower risk of TB development compared with those who continued to smoke (aHR 0.771; 95% CI 0.741–0.892). However, even after smoking cessation, individuals who lost weight were at a significantly higher risk of TB development compared with those who continued to smoke (aHR 1.327; 95% CI 1.119–1.715). CONCLUSIONS: Our findings suggest that smoking is a risk factor for TB and weight maintenance (neither gaining or losing) after quitting smoking might reduce the risk of TB development. |
format | Online Article Text |
id | pubmed-8989195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-89891952022-04-08 Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study Kim, Seung Hoon Park, Yong-Moon Han, Kyungdo Ko, Seung Hyun Kim, Shin Young Song, So Hyang Kim, Chi Hong Hur, Kyu Yeon Kim, Sung Kyoung PLoS One Research Article BACKGROUND: Smoking or weight loss is a risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of TB development. METHODS: We conducted a population-based cohort study using the national database in Republic of Korea. Of the 10,490,491 subjects who underwent health check-up in 2009, we enrolled 9,953,124 subjects without a previous TB history and followed them until 2017. We divided all study participants into the following three groups: never, former, and current smokers. The primary endpoint was newly developed TB. RESULTS: Among 9,953,124 subjects analyzed, 5,922,845 (59.5%) were never smokers, 1,428,209 (14.4%) were former smokers, and 2,602,080 (26.1%) were current smokers. The risk of TB development was significantly higher in current smokers than in never smokers (adjusted hazard ratio (aHR) 1.158; 95% confidence interval [CI] 1.131–1.186). Among current smokers, individuals who stopped smoking and maintained weight after baseline evaluation had a significantly lower risk of TB development compared with those who continued to smoke (aHR 0.771; 95% CI 0.741–0.892). However, even after smoking cessation, individuals who lost weight were at a significantly higher risk of TB development compared with those who continued to smoke (aHR 1.327; 95% CI 1.119–1.715). CONCLUSIONS: Our findings suggest that smoking is a risk factor for TB and weight maintenance (neither gaining or losing) after quitting smoking might reduce the risk of TB development. Public Library of Science 2022-04-07 /pmc/articles/PMC8989195/ /pubmed/35390038 http://dx.doi.org/10.1371/journal.pone.0266262 Text en © 2022 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Seung Hoon Park, Yong-Moon Han, Kyungdo Ko, Seung Hyun Kim, Shin Young Song, So Hyang Kim, Chi Hong Hur, Kyu Yeon Kim, Sung Kyoung Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study |
title | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study |
title_full | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study |
title_fullStr | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study |
title_full_unstemmed | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study |
title_short | Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study |
title_sort | association of weight change following smoking cessation with the risk of tuberculosis development: a nationwide population-based cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989195/ https://www.ncbi.nlm.nih.gov/pubmed/35390038 http://dx.doi.org/10.1371/journal.pone.0266262 |
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