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Malignant glioma subset from actuate 1801: Phase I/II study of 9-ING-41, GSK-3β inhibitor, monotherapy or combined with chemotherapy for refractory malignancies

BACKGROUND: GSK3β serine/threonine kinase regulates metabolism and glycogen biosynthesis. GSK3β overexpression promotes progression and resistance through NF-κB and p53 apoptotic pathways. GSK3β inhibits immunomodulation by downregulating PD-L1 and LAG-3 checkpoints and increasing NK and T-cell tumo...

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Detalles Bibliográficos
Autores principales:	Odia, Yazmin, Cavalcante, Ludimila, Safran, Howard, Powell, Steven Francis, Munster, Pamela N, Ma, Wen Wee, Carneiro, Benedito A, Bastos, Bruno R, Mikrut, Stacy, Mikrut, William, Giles, Francis J, Sahebjam, Solmaz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989389/ https://www.ncbi.nlm.nih.gov/pubmed/35402914 http://dx.doi.org/10.1093/noajnl/vdac012

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