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Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review)
Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis and lead to oxidative stress that may result in cell death. However, the tumor cell microenvironment is dynamic and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989428/ https://www.ncbi.nlm.nih.gov/pubmed/35293589 http://dx.doi.org/10.3892/ijmm.2022.5121 |
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author | Liu, Rui Bian, Yan Liu, Lin Liu, Lianchang Liu, Xiaodong Ma, Shumei |
author_facet | Liu, Rui Bian, Yan Liu, Lin Liu, Lianchang Liu, Xiaodong Ma, Shumei |
author_sort | Liu, Rui |
collection | PubMed |
description | Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis and lead to oxidative stress that may result in cell death. However, the tumor cell microenvironment is dynamic and responds to radiotherapy by activating numerous cellular signaling pathways. By scavenging excess ROS, the activity levels of the endogenous antioxidant enzymes result in radioresistance and worsen the clinical outcomes. To assess the full potential of radiotherapy, it is essential to explore the underlying mechanisms of oxidative stress in radiotherapy for potential target identification. The present review article summarized recent data demonstrating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) as a powerful transcription factor and one of the major cellular defense mechanisms that protect against oxidative stress in response to radiotherapy; the glutathione (GSH) and thioredoxin (Trx) systems complement each other and are effective antioxidant mechanisms associated with the protection of cancer cells from radiation damage. In addition, it is suggested that dual targeting to inhibit GSH and Trx enzymes may be a potential strategy for the development of radiosensitive and radioprotective drugs. |
format | Online Article Text |
id | pubmed-8989428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-89894282022-04-11 Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) Liu, Rui Bian, Yan Liu, Lin Liu, Lianchang Liu, Xiaodong Ma, Shumei Int J Mol Med Articles Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis and lead to oxidative stress that may result in cell death. However, the tumor cell microenvironment is dynamic and responds to radiotherapy by activating numerous cellular signaling pathways. By scavenging excess ROS, the activity levels of the endogenous antioxidant enzymes result in radioresistance and worsen the clinical outcomes. To assess the full potential of radiotherapy, it is essential to explore the underlying mechanisms of oxidative stress in radiotherapy for potential target identification. The present review article summarized recent data demonstrating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) as a powerful transcription factor and one of the major cellular defense mechanisms that protect against oxidative stress in response to radiotherapy; the glutathione (GSH) and thioredoxin (Trx) systems complement each other and are effective antioxidant mechanisms associated with the protection of cancer cells from radiation damage. In addition, it is suggested that dual targeting to inhibit GSH and Trx enzymes may be a potential strategy for the development of radiosensitive and radioprotective drugs. D.A. Spandidos 2022-05 2022-03-15 /pmc/articles/PMC8989428/ /pubmed/35293589 http://dx.doi.org/10.3892/ijmm.2022.5121 Text en Copyright: © Liu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Liu, Rui Bian, Yan Liu, Lin Liu, Lianchang Liu, Xiaodong Ma, Shumei Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) |
title | Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) |
title_full | Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) |
title_fullStr | Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) |
title_full_unstemmed | Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) |
title_short | Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) |
title_sort | molecular pathways associated with oxidative stress and their potential applications in radiotherapy (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989428/ https://www.ncbi.nlm.nih.gov/pubmed/35293589 http://dx.doi.org/10.3892/ijmm.2022.5121 |
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