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Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery
BACKGROUND: Patients with generalized epilepsy who had lateralized EEG abnormalities after corpus callosotomy (CC) occasionally undergo subsequent surgeries to control intractable epilepsy. OBJECTIVES: This study evaluated retrospectively the combination of EEG multiscale entropy (MSE) and FDG-PET f...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989433/ https://www.ncbi.nlm.nih.gov/pubmed/35401399 http://dx.doi.org/10.3389/fneur.2022.831126 |
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author | Kosugi, Kenzo Iijima, Keiya Yokosako, Suguru Takayama, Yutaro Kimura, Yuiko Kaneko, Yuu Sumitomo, Noriko Saito, Takashi Nakagawa, Eiji Sato, Noriko Iwasaki, Masaki |
author_facet | Kosugi, Kenzo Iijima, Keiya Yokosako, Suguru Takayama, Yutaro Kimura, Yuiko Kaneko, Yuu Sumitomo, Noriko Saito, Takashi Nakagawa, Eiji Sato, Noriko Iwasaki, Masaki |
author_sort | Kosugi, Kenzo |
collection | PubMed |
description | BACKGROUND: Patients with generalized epilepsy who had lateralized EEG abnormalities after corpus callosotomy (CC) occasionally undergo subsequent surgeries to control intractable epilepsy. OBJECTIVES: This study evaluated retrospectively the combination of EEG multiscale entropy (MSE) and FDG-PET for identifying lateralization of the epileptogenic zone after CC. METHODS: This study included 14 patients with pharmacoresistant epilepsy who underwent curative epilepsy surgery after CC. Interictal scalp EEG and FDG-PET obtained after CC were investigated to determine (1) whether the MSE calculated from the EEG and FDG-PET findings was lateralized to the surgical side, and (2) whether the lateralization was associated with seizure outcomes. RESULTS: Seizure reduction rate was higher in patients with lateralized findings to the surgical side than those without (MSE: p < 0.05, FDG-PET: p < 0.05, both: p < 0.01). Seizure free rate was higher in patients with lateralized findings in both MSE and FDG-PET than in those without (p < 0.05). CONCLUSIONS: This study demonstrated that patients with lateralization of MSE and FDG-PET to the surgical side had better seizure outcomes. The combination of MSE and conventional FDG-PET may help to select surgical candidates for additional surgery after CC with good postoperative seizure outcomes. |
format | Online Article Text |
id | pubmed-8989433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89894332022-04-08 Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery Kosugi, Kenzo Iijima, Keiya Yokosako, Suguru Takayama, Yutaro Kimura, Yuiko Kaneko, Yuu Sumitomo, Noriko Saito, Takashi Nakagawa, Eiji Sato, Noriko Iwasaki, Masaki Front Neurol Neurology BACKGROUND: Patients with generalized epilepsy who had lateralized EEG abnormalities after corpus callosotomy (CC) occasionally undergo subsequent surgeries to control intractable epilepsy. OBJECTIVES: This study evaluated retrospectively the combination of EEG multiscale entropy (MSE) and FDG-PET for identifying lateralization of the epileptogenic zone after CC. METHODS: This study included 14 patients with pharmacoresistant epilepsy who underwent curative epilepsy surgery after CC. Interictal scalp EEG and FDG-PET obtained after CC were investigated to determine (1) whether the MSE calculated from the EEG and FDG-PET findings was lateralized to the surgical side, and (2) whether the lateralization was associated with seizure outcomes. RESULTS: Seizure reduction rate was higher in patients with lateralized findings to the surgical side than those without (MSE: p < 0.05, FDG-PET: p < 0.05, both: p < 0.01). Seizure free rate was higher in patients with lateralized findings in both MSE and FDG-PET than in those without (p < 0.05). CONCLUSIONS: This study demonstrated that patients with lateralization of MSE and FDG-PET to the surgical side had better seizure outcomes. The combination of MSE and conventional FDG-PET may help to select surgical candidates for additional surgery after CC with good postoperative seizure outcomes. Frontiers Media S.A. 2022-03-24 /pmc/articles/PMC8989433/ /pubmed/35401399 http://dx.doi.org/10.3389/fneur.2022.831126 Text en Copyright © 2022 Kosugi, Iijima, Yokosako, Takayama, Kimura, Kaneko, Sumitomo, Saito, Nakagawa, Sato and Iwasaki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Kosugi, Kenzo Iijima, Keiya Yokosako, Suguru Takayama, Yutaro Kimura, Yuiko Kaneko, Yuu Sumitomo, Noriko Saito, Takashi Nakagawa, Eiji Sato, Noriko Iwasaki, Masaki Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery |
title | Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery |
title_full | Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery |
title_fullStr | Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery |
title_full_unstemmed | Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery |
title_short | Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery |
title_sort | low eeg gamma entropy and glucose hypometabolism after corpus callosotomy predicts seizure outcome after subsequent surgery |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989433/ https://www.ncbi.nlm.nih.gov/pubmed/35401399 http://dx.doi.org/10.3389/fneur.2022.831126 |
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