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Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a

Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene Ube3a. Comparing newly generated mouse models for Ube3a downregulation (models of Angelman syndrome) vs. Ube3a upregulation (models for autism), we find reciprocal effects of Ube3a gene dosage on phenotypes associat...

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Detalles Bibliográficos
Autores principales:	Shi, Shu-qun, Mahoney, Carrie E., Houdek, Pavel, Zhao, Wenling, Anderson, Matthew P., Zhuo, Xinming, Beaudet, Arthur, Sumova, Alena, Scammell, Thomas E., Johnson, Carl Hirschie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989470/ https://www.ncbi.nlm.nih.gov/pubmed/35401134 http://dx.doi.org/10.3389/fnbeh.2022.837523

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