Global chromosome rearrangement induced by CRISPR-Cas9 reshapes the genome and transcriptome of human cells

Chromosome rearrangement plays important roles in development, carcinogenesis and evolution. However, its mechanism and subsequent effects are not fully understood. Large-scale chromosome rearrangement has been performed in the simple eukaryote, wine yeast, but the relative research in mammalian cel...

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Detalles Bibliográficos
Autores principales: Liu, Ying, Ma, Guangwei, Gao, Zenghong, Li, Jian, Wang, Jin, Zhu, Xiangping, Ma, Ruowu, Yang, Jiawen, Zhou, Yiting, Hu, Kaishun, Zhang, Yin, Guo, Yabin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989517/
https://www.ncbi.nlm.nih.gov/pubmed/35244719
http://dx.doi.org/10.1093/nar/gkac153

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