7,8-Dihydro-8-oxo-1,N(6)-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli

This work investigated the structural and biological properties of DNA containing 7,8-dihydro-8-oxo-1,N(6)-ethenoadenine (oxo-ϵA), a non-natural synthetic base that combines structural features of two naturally occurring DNA lesions (7,8-dihydro-8-oxoadenine and 1,N(6)-ethenoadenine). UV-, CD-, NMR...

Descripción completa

Detalles Bibliográficos
Autores principales: Aralov, Andrey V, Gubina, Nina, Cabrero, Cristina, Tsvetkov, Vladimir B, Turaev, Anton V, Fedeles, Bogdan I, Croy, Robert G, Isaakova, Ekaterina A, Melnik, Denis, Dukova, Svetlana, Ryazantsev, Dmitriy Y, Khrulev, Alexei A, Varizhuk, Anna M, González, Carlos, Zatsepin, Timofei S, Essigmann, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989528/
https://www.ncbi.nlm.nih.gov/pubmed/35234900
http://dx.doi.org/10.1093/nar/gkac148

Ejemplares similares

Ejemplares similares