BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with physiological decline and stem cell exhaustion. However, whether the circadian machinery directly regulates stem cell aging, especially in primates, remains poorly understood. In this study, we found that de...

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Detalles Bibliográficos
Autores principales: Liang, Chuqian, Ke, Qiong, Liu, Zunpeng, Ren, Jie, Zhang, Weiqi, Hu, Jianli, Wang, Zehua, Chen, Hong, Xia, Kai, Lai, Xingqiang, Wang, Qiaoran, Yang, Kuan, Li, Wei, Wu, Zeming, Wang, Chao, Yan, Haoteng, Jiang, Xiaoyu, Ji, Zhejun, Ma, Miyang, Long, Xiao, Wang, Si, Wang, Huating, Sun, Hao, Belmonte, Juan Carlos Izpisua, Qu, Jing, Xiang, Andy Peng, Liu, Guang-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989534/
https://www.ncbi.nlm.nih.gov/pubmed/35286396
http://dx.doi.org/10.1093/nar/gkac146

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