Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing

Precision epigenome editing has gained significant attention as a method to modulate gene expression without altering genetic information. However, a major limiting factor has been that the gene expression changes are often transient, unlike the life-long epigenetic changes that occur frequently in...

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Detalles Bibliográficos
Autores principales: O’Geen, Henriette, Tomkova, Marketa, Combs, Jacquelyn A, Tilley, Emma K, Segal, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989539/
https://www.ncbi.nlm.nih.gov/pubmed/35234927
http://dx.doi.org/10.1093/nar/gkac123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989539/
https://www.ncbi.nlm.nih.gov/pubmed/35234927
http://dx.doi.org/10.1093/nar/gkac123

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