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Predicting base editing outcomes using position-specific sequence determinants

CRISPR/Cas base editors promise nucleotide-level control over DNA sequences, but the determinants of their activity remain incompletely understood. We measured base editing frequencies in two human cell lines for two cytosine and two adenine base editors at ∼14 000 target sequences and find that bas...

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Detalles Bibliográficos
Autores principales:	Pallaseni, Ananth, Peets, Elin Madli, Koeppel, Jonas, Weller, Juliane, Vanderstichele, Thomas, Ho, Uyen Linh, Crepaldi, Luca, van Leeuwen, Jolanda, Allen, Felicity, Parts, Leopold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989541/ https://www.ncbi.nlm.nih.gov/pubmed/35286377 http://dx.doi.org/10.1093/nar/gkac161

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